Non-linear relationship between basal serum albumin concentration and cardiac arrest in critically ill patients with end-stage renal disease: a cross-sectional study.
Non-linear relationship between basal serum albumin concentration and cardiac arrest in critically ill patients with end-stage renal disease: a cross-sectional study.
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DOI：
10.1136/bmjopen-2021-051721
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发表时间：
2022-02-08
期刊：
影响因子：
2.9
通讯作者：
Yan R
中科院分区：
文献类型：
--
作者：
Zeng YQ;Qin ZA;Guo ZW;Li B;Yu HY;Chen RX;Tang YQ;Hu KJ;Guan CJ;Yan R
本研究旨在探讨重症监护室（ICU）中终末期肾病危重患者血清白蛋白浓度与心脏骤停风险之间的关系。这是次要分析。2014年至2015年的菲利普电子-ICU协作数据库。本研究纳入了4990例诊断为终末期肾病的危重患者。关注的暴露量为血清白蛋白浓度。结局变量为心脏骤停。观察到血清白蛋白浓度与心脏骤停风险之间存在非线性关系，调整潜在混杂因素后的拐点为3.26 g/dL。拐点左右两侧的效应量和CI分别为0.88（0.65 ~ 1.19）和0.32（0.16 ~ 0.64）。在3.26-5.6 g/dL的白蛋白范围内，血清水平每升高1 g/dL，终末期肾病重症患者的心脏骤停风险降低68%。
The aim of our study was to investigate the association between serum albumin concentration and the risk of cardiac arrest in critically ill patients with end-stage renal disease in the intensive care unit (ICU). This was a secondary analysis. The Phillip electronic-ICU collaborative database from 2014 to 2015. This study included 4990 critically ill patients diagnosed with end-stage renal disease. The exposure of interest was serum albumin concentration. The outcome variable was cardiac arrest. A non-linear relationship was observed between serum albumin concentration and risk of cardiac arrest, with an inflection point of 3.26 g/dL after adjusting for potential confounders. The effect sizes and the CIs on the left and right sides of the inflection point were 0.88 (0.65 to 1.19) and 0.32 (0.16 to 0.64), respectively. Within an albumin range of 3.26–5.6 g/dL, each 1 g/dL increase in serum levels is associated with a 68% decrease of the risk of cardiac arrest in critically ill patients with end-stage renal disease.
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影响因子：
24
作者：
Buxton, Alfred E.;Calkins, Hugh;Redberg, Rita F.
通讯作者：
Redberg, Rita F.
DOI：
10.1016/j.cvsm.2016.09.009
发表时间：
2017-03-01
影响因子：
1.9
作者：
Conner, Bobbi J.
通讯作者：
Conner, Bobbi J.
影响因子：
9.8
作者：
Pollard TJ;Johnson AEW;Raffa JD;Celi LA;Mark RG;Badawi O
通讯作者：
Badawi O
DOI：
10.1053/j.ajkd.2010.12.023
发表时间：
2011-06
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Wagner M;Ansell D;Kent DM;Griffith JL;Naimark D;Wanner C;Tangri N
通讯作者：
Tangri N
影响因子：
19.6
作者：
Pifer, TB;McCullough, KP;Young, EW
通讯作者：
Young, EW