Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia.
Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia.
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DOI：
10.1038/s41598-021-85977-x
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发表时间：
2021-03-22
影响因子：
4.6
通讯作者：
Broadley MR
中科院分区：
文献类型：
--
作者：
Belay A;Gashu D;Joy EJM;Lark RM;Chagumaira C;Likoswe BH;Zerfu D;Ander EL;Young SD;Bailey EH;Broadley MR
锌是人体健康所必需的营养物质。在埃塞俄比亚，据报告锌缺乏症的发病率很高。为了探索埃塞俄比亚人口锌状况的人口统计学差异和空间相关性，我们分析了2015年埃塞俄比亚国家微量营养素调查(ENMS)的存档血清样本(n = 3373)，这是一项对埃塞俄比亚所有9个地区和两个城市管理局进行的幼儿、学龄儿童、育龄妇女和男子的横断面调查。使用电感耦合等离子体质谱(ICPMS)测量的血清锌浓度，在调整炎症状态后，与基于年龄、性别、空腹状态和采血时间的阈值进行比较。人群血清锌浓度中位数为57.5gμg dL−1。总体而言，估计有72%的人群缺锌，在所有人口群体中患病率都很高。空间统计分析表明，在距离45公里的范围内，WRA的锌状况存在空间依赖性。缺锌在短距离内具有空间相关性。尽管大多数地区的WRA很可能是缺锌的，但缺锌的流行率在地区范围内以及城乡居民之间存在差异，这表明有空间探索这种差异的驱动因素，优先考虑营养干预，并设计更具代表性的监测计划。
Zinc (Zn) is an essential nutrient for human health. In Ethiopia, a high prevalence of Zn deficiency has been reported. To explore demographic variation and spatial dependencies in the Zn status of the Ethiopian population, we analyzed archived serum samples (n = 3373) from the 2015 Ethiopian National Micronutrient Survey (ENMS), a cross-sectional survey of young children, school-age children, women of reproductive age (WRA) and men conducted in all 9 regions and two city administration of Ethiopia. Serum Zn concentrations, measured using inductively coupled plasma-mass spectrometry (ICPMS), were compared to thresholds based on age, sex, fasting status, and time of blood collection, after adjusting for inflammation status. Median serum Zn concentration of the population was 57.5 μg dL−1. Overall, it is estimated that 72% of the population was Zn deficient, with high prevalence in all demographic groups. Spatial statistical analysis showed that there was spatial dependence in Zn status of WRA at distances of up to 45 km. Zinc deficiency is spatially dependent over short distances. Although WRA in most areas are likely to be Zn deficient, prevalence of deficiency varies at regional scale and between rural and urban inhabitants, suggesting there is scope to explore drivers of this variation, prioritize nutritional interventions, and to design more representative surveillance programs.
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影响因子：
7.1
作者：
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通讯作者：
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作者：
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通讯作者：
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