Modulation of interhemispheric alpha-band connectivity by transcranial alternating current stimulation
Modulation of interhemispheric alpha-band connectivity by transcranial alternating current stimulation
复制标题
经颅交流电刺激调节半球间 α 波段连通性
DOI：
10.1101/484014
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发表时间：
2018
影响因子：
7.7
通讯作者：
A. Engel
中科院分区：
文献类型：
--
作者：
B. Schwab;J. Misselhorn;A. Engel
大脑中的长距离功能连接被认为是认知的基础，并且已知在许多神经精神疾病中会发生改变。为了改变这种独立于感觉输入的耦合，非侵入性脑刺激可能具有最大的价值。特别是，经颅交流电刺激（tACS）已被提出来调制振荡耦合，而频率和空间特定的连接修改的证据是失踪至今。因此，我们研究了10 Hz双焦点高清tACS对α耦合的后效。健康的参与者以平衡的顺序受到刺激：（1）同相，两个半球中具有相同的电场;（2）反相，两个半球中具有相反的电场;以及（3）抖动相位，由微妙的频率变化产生，不断改变两个场之间的相对相位。全球前后刺激EEG连接的变化较大的同相刺激比反相或抖动相刺激。连接变化的差异仅限于刺激频带，并在刺激偏移后100 s的时间窗内衰减。源重建局部刺激枕顶叶区之间的最大效果。总之，双灶性α-tACS的相对相位决定了靶向区域之间的α-带连接性移位。因此，我们建议双焦点高清晰度tACS作为一种工具，专门调制远距离皮质-皮质耦合，持续时间超过电刺激期。作者摘要经颅交流电刺激（tACS）向头部输送有节奏变化的电流，目的是非侵入性刺激神经组织。最近，tACS被提议在局部同步神经振荡，并且当同时应用于多个部位时，在远程脑区域之间同步神经振荡。神经信号的动态耦合被认为是大脑正常功能的关键，其调制可能具有巨大的研究和临床应用潜力。然而，频率和空间特定的修改功能连接的tACS仍然有待证明。通过优化的刺激蒙太奇和从EEG信号重建神经源，我们能够在刺激偏移后长达100 s的时间窗口内证明tACS对功能连接的影响。特别是，这些影响是特定于刺激频率的，并集中在刺激的皮层区域。因此，tACS可能有助于在实验环境中操纵功能连接，以探测对大脑功能的要求。此外，在未来的研究中，患病大脑中的异常耦合可以通过重复刺激来靶向。
Long-range functional connectivity in the brain is considered fundamental for cognition and is known to be altered in many neuropsychiatric disorders. To modify such coupling independent of sensory input, non-invasive brain stimulation could be of utmost value. In particular, transcranial alternating current stimulation (tACS) has been proposed to modulate oscillatory coupling, while evidence for frequency- and space-specific modification of connectivity is missing so far. Therefore, we investigated the aftereffects of bifocal high-definition tACS at 10 Hz on alpha-coupling. Healthy participants were stimulated in counter-balanced order (1) in-phase, with identical electric fields in both hemispheres, (2) anti-phase, with phase-reversed electric fields in the two hemispheres, and (3) jittered-phase, generated by subtle frequency shifts continuously changing the relative phase between the two fields. Global pre-post stimulation changes in EEG connectivity were larger for in-phase stimulation than for anti-phase or jittered-phase stimulation. The differences in connectivity change were restricted to the stimulated frequency band and decayed within a time window of 100 s after stimulation offset. Source reconstruction localized the maximum effect between the stimulated occipito-parietal areas. In conclusion, the relative phase of bifocal alpha-tACS determined alpha-band connectivity shifts between the targeted regions. We thus suggest bifocal high-definition tACS as a tool to specifically modulate long-range cortico-cortical coupling which outlasts the electrical stimulation period. Author summary Transcranial alternating current stimulation (tACS) delivers rhythmically varying electric currents to the head with the goal of non-invasively stimulating neural tissue. Recently, tACS was proposed to synchronize neural oscillations locally and, when applied concurrently at multiple sites, between remote brain areas. Dynamic coupling of neural signals is considered essential for normal functioning of the brain, and its modulation may carry great potential for both research and clinical use. Nevertheless, frequency- and space-specific modification of functional connectivity by tACS still remains to be shown. With an optimized stimulation montage and reconstruction of neural sources from EEG signals, we were able to demonstrate effects of tACS on functional connectivity in a time window up to 100 s after stimulation offset. In particular, the effects were specific to the stimulated frequency and focused on the stimulated cortical areas. tACS may therefore help to manipulate functional connectivity in experimental settings to probe claims on brain function. Moreover, abnormal coupling in the diseased brain could in future studies be targeted by repetitive stimulation.
影响因子：
3.7
作者：
Zaehle T;Rach S;Herrmann CS
通讯作者：
Herrmann CS
影响因子：
5.7
作者：
Noury, Nima;Hipp, Joerg F.;Siegel, Markus
通讯作者：
Siegel, Markus
影响因子：
9.8
作者：
Helfrich RF;Knepper H;Nolte G;Strüber D;Rach S;Herrmann CS;Schneider TR;Engel AK
通讯作者：
Engel AK