Neural systems mediating the inhibition of cocaine-seeking behaviors.
Neural systems mediating the inhibition of cocaine-seeking behaviors.
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DOI：
10.1016/j.pbb.2017.07.006
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
LaLumiere RT
中科院分区：
文献类型：
--
作者：
Muller Ewald VA;LaLumiere RT
在过去的几十年里，研究的目标是调节可卡因寻找行为的神经生物学，主要是希望确定治疗可卡因成瘾的潜在靶点。虽然这些工作主要集中在驱动可卡因寻找的系统上，但最近，研究可卡因相关行为的抑制在揭示抑制可卡因寻找的神经系统方面取得了重大进展。这些系统包括下缘皮质、伏隔核外壳和下丘脑。这一领域的研究主要集中在下缘皮质，因为该区域的活动似乎可以减弱恢复过程中寻求可卡因的行为，并有助于灭绝学习。然而，这一区域的主要功能理论，包括它在其他类型的奖励寻求和学习中的作用，仍有待确定。此外，参与减弱可卡因寻找行为的其他区域与下缘皮质之间的确切关系仍不清楚。病毒载体结合光遗传学、化学遗传学和其他方法使用的最新进展极大地影响了我们研究依赖可卡因相关记忆的抑制行为的系统的能力。这篇综述将介绍目前对抑制这种行为的神经生物学的理解，特别是这种记忆的消失，并探索病毒载体靶向特定大脑回路如何开始改变并将继续丰富我们对这一问题的知识。
Over the past decades, research has targeted the neurobiology regulating cocaine-seeking behaviors, largely in the hopes of identifying potential targets for the treatment of cocaine addiction. Although much of this work has focused on those systems driving cocaine seeking, recently, studies examining the inhibition of cocaine-related behaviors have made significant progress in uncovering the neural systems that attenuate cocaine seeking. Such systems include the infralimbic cortex, nucleus accumbens shell, and hypothalamus. Research in this field has focused largely on the infralimbic cortex, as activity in this region appears to attenuate cocaine seeking during reinstatement and contribute to extinction learning. However, an overarching theory of function for this region that includes its role in other types of reward seeking and learning remains to be determined. Furthermore, the precise relationship between other regions involved in attenuating cocaine-seeking behavior and the infralimbic cortex remains unclear. Recent advances in the use of viral vectors combined with optogenetics, chemogenetics, and other approaches have greatly affected our capacity to investigate those systems inhibiting behavior dependent on cocaine-associated memories. This review will present current understanding regarding the neurobiology underlying the inhibition of such behaviors, especially focusing on the extinction of such memories, and explore how viral-vector targeting of specific brain circuits has begun to alter, and will continue to enrich, our knowledge regarding this issue.
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影响因子：
3.7
作者：
Bechara, A;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
3
作者：
Cassaday HJ;Nelson AJ;Pezze MA
通讯作者：
Pezze MA
影响因子：
5.3
作者：
Augur, Isabel F.;Wyckoff, Andrew R.;Peters, Jamie
通讯作者：
Peters, Jamie
DOI：
10.1523/jneurosci.0005-12.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bossert JM;Stern AL;Theberge FR;Marchant NJ;Wang HL;Morales M;Shaham Y
通讯作者：
Shaham Y
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL