Toll-like receptors in Alzheimer's disease.
Toll-like receptors in Alzheimer's disease.
复制标题
DOI：
10.1007/978-3-642-00549-7_8
复制
发表时间：
2009
影响因子：
--
通讯作者：
Reed-Geaghan, Erin G.
中科院分区：
文献类型：
--
作者：
Landreth, Gary E.;Reed-Geaghan, Erin G.
Alzheimer’s disease (AD) is characterized by the formation of insoluble deposits of β-amyloid (Aβ) within the parenchyma of the brain. These deposits are associated with a robust microglial-mediated inflammatory response. Recent work has demonstrated that Toll like receptors (TLRs) participate in this inflammatory response. This chapter reviews the mechanisms whereby TLRs contribute to induction of a microglial inflammatory response to promote AD pathogenesis. Specifically the involvement of CD14 and the TLRs in microglial activation is delineated. The TLR-mediated microglial response has both beneficial roles in stimulating phagocytosis as well as detrimental roles in the Aβ-stimulated release of neurotoxic products.
登录
查看更多内容
影响因子：
56.9
作者：
Blander, JM;Medzhitov, R
通讯作者：
Medzhitov, R
影响因子：
8.3
作者：
Gorelick, PB
通讯作者：
Gorelick, PB
影响因子：
5.3
作者：
Bolmont, Tristan;Haiss, Florent;Calhoun, Michael E.
通讯作者：
Calhoun, Michael E.
影响因子：
25
作者：
Davalos, D;Grutzendler, J;Gan, WB
通讯作者：
Gan, WB
影响因子：
4.8
作者：
Chen, KQ;Iribarren, P;Wang, JM
通讯作者：
Wang, JM