Regulatory effect of long-stranded non-coding RNA-CRNDE on neurodegeneration during retinal ischemia-reperfusion.
Regulatory effect of long-stranded non-coding RNA-CRNDE on neurodegeneration during retinal ischemia-reperfusion.
复制标题
长链非编码RNA-CRNDE对视网膜缺血再灌注神经退行性变的调节作用
DOI：
10.1016/j.heliyon.2022.e10994
复制
发表时间：
2022-10
期刊：
影响因子：
4
通讯作者：
Jiang, Qin
中科院分区：
文献类型：
--
作者：
Sun, Ting-Ting;Li, Xiu-Miao;Zhu, Jun-Ya;Yao, Wen;Yang, Tian-Jing;Meng, Xiang-Rui;Yao, Jin;Jiang, Qin
缺血/再灌注（I/R）损伤是许多眼部疾病的常见病理机制。 I/R 的特点是微血管功能障碍和神经变性。然而，缺血再灌注引起的神经退行性变的机制仍然很大程度上未知。本研究表明，视网膜缺血再灌注（RIR）后长链非编码RNA-CRNDE的表达显着上调。 LncRNA-CRNDE 敲低可减轻 RIR 损伤引起的视网膜神经变性，如反应性神经胶质增生减少和视网膜细胞损失减少所示。此外，lncRNA-CRNDE敲低直接调节Müller细胞功能并间接影响体外RGC功能。此外，lncRNA-CRNDE 敲低导致 RIR 后多种细胞因子的释放显着减少。这项研究表明 lncRNA-CRNDE 是 RIR 的一个有前途的治疗靶点。视网膜缺血再灌注损伤；长链非编码RNA；视网膜神经变性。
Ischemia/reperfusion (I/R) injury is a common pathological mechanism involved in many ocular diseases. I/R is characterized by microvascular dysfunction and neurodegeneration. However, the mechanisms of neurodegeneration induced by I/R remain largely unknown. This study showed that the expression of long non-coding RNA-CRNDE was significantly upregulated after retinal ischemia-reperfusion (RIR). LncRNA-CRNDE knockdown alleviated retinal neurodegeneration induced by RIR injury, as shown by decreased reactive gliosis and reduced retinal cells loss. Furthermore, lncRNA-CRNDE knockdown directly regulated Müller cell function and indirectly affected RGC function in vitro. In addition, lncRNA-CRNDE knockdown led to a significant reduction in the release of several cytokines after RIR. This study suggests that lncRNA-CRNDE is a promising therapeutic target for RIR. Retinal ischemia-reperfusion injury; Long non-coding RNA; Retinal neurodegeneration.
登录
查看更多内容
靶向长非编码RNA-AQP4-AS1治疗糖尿病视网膜神经血管功能障碍
影响因子：
11.1
作者：
Li X;Zhu J;Zhong Y;Liu C;Yao M;Sun Y;Yao W;Ni X;Zhou F;Yao J;Jiang Q
通讯作者：
Jiang Q
影响因子：
64.8
作者：
Ding H;Smith RG;Poleg-Polsky A;Diamond JS;Briggman KL
通讯作者：
Briggman KL
影响因子：
15.1
作者：
Kim BJ;Braun TA;Wordinger RJ;Clark AF
通讯作者：
Clark AF
影响因子：
4.4
作者：
Bai, Yujing;Sivori, Delia;Saragovi, H. Uri
通讯作者：
Saragovi, H. Uri
影响因子：
64.5
作者：
Kopp F;Mendell JT
通讯作者：
Mendell JT