Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer.
Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer.
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DOI：
10.1016/j.ygyno.2008.08.028
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发表时间：
2009-01
影响因子：
4.7
通讯作者：
Grigsby, Perry W.
中科院分区：
文献类型：
--
作者：
Brooks, Rebecca A.;Rader, Janet S.;Dehdashti, Farrokh;Mutch, David G.;Powell, Matthew A.;Thaker, Premal H.;Siegel, Barry A.;Grigsby, Perry W.
评估FDG-PET检测有症状与无症状宫颈癌患者复发后的生存率。这是一项前瞻性登记研究，纳入了103例接受确定性放化疗治疗的晚期宫颈癌患者，这些患者在治疗后3个月的FDG-PET中未显示FDG摄取异常（完全代谢反应，CMR）。他们的中位年龄为48岁（范围26-84岁）。临床分期为Ib 38例，IIa 1例，IIb 39例，IIIb 25例。所有患者均接受了后续监测FDG-PET。根据监测FDG-PET时的症状状态对患者进行分组。分析复发部位和生存数据。从治疗后3个月FDG-PET到首次监测FDG-PET的中位时间为13个月。25例患者（25/103; 24%）在监测FDG-PET时有症状，其中21例FDG-PET结果提示复发。78例患者（78/103; 76%）无症状，其中9例PET检测到肿瘤复发。所有复发均经活检或放射学进展证实。21例有症状的患者中，局部复发4例，远处复发17例。9例无症状患者中，8例为孤立性局部疾病，1例为远处疾病.所有患者均接受复发治疗。有症状复发的3年病因特异性生存率为19%，无症状复发为59%（p=0.09）。监测FDG-PET可以检测到无症状的复发性疾病，可能适合挽救治疗。有必要对监测PET进行前瞻性研究。
To evaluate survival after detection of recurrent cervical cancer by FDG-PET in symptomatic versus asymptomatic patients. This is a prospective registry study of 103 patients treated with definitive chemoradiation for advanced cervical cancer who demonstrated no abnormal FDG uptake (a complete metabolic response, CMR) on their 3-month posttherapy FDG-PET. Their median age was 48 years (range 26-84). The clinical stages were Ib in 38, IIa in 1, IIb in 39, and IIIb in 25. All patients underwent subsequent surveillance FDG-PET. Patients were grouped according to symptom status at the time of the surveillance FDG-PET. Recurrence sites and survival data were analyzed. The median time from the 3-month posttherapy FDG-PET to the first surveillance FDG-PET was 13 months. 25 patients (25/103; 24%) were symptomatic at the time of surveillance FDG-PET and 21 of these had FDG-PET findings indicative of recurrence. 78 patients (78/103; 76%) were asymptomatic and 9 of these had tumor recurrence detected by PET. All recurrences were confirmed by biopsy or radiologic progression. The recurrences in the 21 symptomatic patients were loco regional in 4 and distant in 17. The 9 asymptomatic patients had isolated loco regional disease in 8 and distant disease in 1. All patients received treatment for recurrence. The three year cause-specific survival for symptomatic recurrences was 19% versus 59% for asymptomatic recurrences (p=0.09). Surveillance FDG-PET can detect asymptomatic recurrent disease that is potentially amenable to salvage therapy. Prospective investigation of surveillance PET is warranted.
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影响因子：
2.7
作者：
BRESLOW, N
通讯作者：
BRESLOW, N
影响因子：
45.3
作者：
Grigsby, PW;Siegel, BA;Dehdashti, F
通讯作者：
Dehdashti, F
影响因子：
4.7
作者：
Chung, Hyun Hoon;Kim, Seok-Ki;Park, Sang-Yoon
通讯作者：
Park, Sang-Yoon
影响因子：
120.7
作者：
Schwarz, Julie K.;Siegel, Barry A.;Grigsby, Perry W.
通讯作者：
Grigsby, Perry W.
影响因子：
45.3
作者：
Grigsby, PW;Siegel, BA;Zoberi, I
通讯作者：
Zoberi, I