A viscoelastic alginate-based hydrogel network coordinated with spermidine for periodontal ligament regeneration.
A viscoelastic alginate-based hydrogel network coordinated with spermidine for periodontal ligament regeneration.
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DOI：
10.1093/rb/rbad009
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发表时间：
2023
影响因子：
6.7
通讯作者：
Xu, Feng
中科院分区：
文献类型：
--
作者：
Zhang, Songbai;Jia, Yuanbo;Liu, Jingyi;Feng, Fan;Wei, Zhao;Zhang, Min;Xu, Feng
关键词：
牙周炎可引起不可逆的牙周韧带缺损，其再生是牙周炎临床治疗的主要障碍。植入水凝胶释放抗炎药物是促进PDL再生的一种很有前景的治疗方法。然而，现有的水凝胶系统不能模拟天然牙周组织的典型粘弹性特征，这可能在组织再生中发挥重要作用。与此同时，机械线索和生化因子对PDL再生的协同效应仍然难以捉摸。在本研究中，我们通过硼酸酯和B-N配位键将苯硼酸修饰的海藻酸盐与抗炎剂（亚精胺）结合，制备了一种双交联粘弹性水凝胶（Alg-PBA/Spd），其中亚精胺会随着水凝胶的降解而释放。Alg-PBA/Spd水凝胶具有生物相容性和可注射性，并且由于动态交联可以快速适应复杂的牙周结构。我们在大鼠模型中证明，粘弹性Alg-PBA/Spd水凝胶显著促进牙周胶原沉积，加速牙周损伤的修复。我们的研究结果表明，粘弹性Alg-PBA/Spd水凝胶是一种很有前途的牙周再生机械-生化协同治疗方法。
Periodontitis can cause irreversible defects in the periodontal ligament (PDL), the regeneration of which is the major obstacle to the clinical treatment of periodontitis. Implanting hydrogel for releasing anti-inflammatory drugs is a promising treatment to promote PDL regeneration. However, existing hydrogel systems fail to mimic the typical viscoelastic feature of native periodontium, which may have been shown as an important role in tissue regeneration. Meanwhile, the synergistic benefits of mechanical cues and biochemical agents for PDL regeneration remain elusive. In this study, we developed a bi-crosslinking viscoelastic hydrogel (Alg-PBA/Spd) by integrating phenylboronic acid-modified alginate with anti-inflammatory agent (spermidine) through borate ester and B–N coordination bonds, where spermidine will be released with the degradation of the hydrogel. Alg-PBA/Spd hydrogel is biocompatible, injectable and can quickly adapt to complex periodontal structures due to the dynamic crosslinking. We demonstrated in rat models that the viscoelastic Alg-PBA/Spd hydrogel significantly promotes the deposition of periodontal collagen and accelerates the repair of periodontal damage. Our results suggest that the viscoelastic Alg-PBA/Spd hydrogel would be a promising mechano-biochemically synergistic treatment for periodontal regeneration.
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