Analysis of Factors That May Affect the Effect of Atropine 0.01% on Myopia Control.
Analysis of Factors That May Affect the Effect of Atropine 0.01% on Myopia Control.
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分析%20of%20因素%20That%20May%20影响%20the%20效果%20of%20阿托品%200.01%%20on%20近视%20控制
DOI：
10.3389/fphar.2020.01081
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发表时间：
2020
影响因子：
5.6
通讯作者：
Qu X
中科院分区：
文献类型：
--
作者：
Zhang X;Wang Y;Zhou X;Qu X
儿童对阿托品治疗的反应不同，预测与更好的近视控制相关的患者因素是重要的。因此，我们旨在评估服用0.01%阿托品的中国儿童近视进展的相关因素。这项回顾性研究包括133名儿童，他们每晚服用0.01%阿托品滴眼液，为期1年。登记的儿童在3个月、6个月和1岁的随访中进行检查。主要结果是临床上有显著的近视进展(等值球镜度数增加-0.75度以上)。使用多变量Logistic分析来确定近视进展的预测因素。平均基线SE为-3.92±2.76D，术后1年SE和轴长平均增加分别为-0.55±0.57D和0.43±0.52 mm。母亲中度近视小于-6D的儿童近视进展的风险显著高于母亲无近视史的儿童(奇比[OR]=2.76，95%可信区间[CI]：1.0 6~7.19，P=0.0382)。剖宫产也是近视进展的危险因素(优势比[OR]=2.35，95%CI：1.3~4.27，P=0.0048)。SE与治疗效果呈线性相关，近视进展的风险随SE的增加而显著降低。在母亲没有近视遗传背景的自然分娩的高度近视儿童中，0.01%阿托品更有效地控制近视。
Children respond differently to atropine treatment, and predicting patient factors associated with better myopia control is important. Therefore, we aimed to evaluate factors related to myopia progression in Chinese children treated with atropine 0.01%. This retrospective study included 133 children who were administered atropine 0.01% eyedrops every night for 1 year. Enrolled children were examined at follow-up visits at 3 and 6 months, and 1 year. The primary outcome was clinically significant myopia progression (over a -0.75 diopter (D) increase in spherical equivalent (SE)). Multivariate logistic analysis was used to identify predictive factors for myopia progression. The mean baseline SE was -3.92 ± 2.76D, and the average increase in SE and axial length at 1 year from baseline were -0.55 ± 0.57D and 0.43 ± 0.52 mm, respectively. The risk of myopia progression significantly increased in children whose mothers had moderate myopia of less than -6D compared to that in children whose mothers had no history of myopia (odd ratio [OR] = 2.76, 95% confidence interval [CI]: 1.06 to 7.19, P = 0.0382). Birth by cesarean section was also a risk factor for myopia progression (odd ratio [OR] = 2.35, 95% CI: 1.30 to 4.27, P = 0.0048). The correlation between SE and treatment efficiency was linear, and the risk of myopia progression significantly decreased with increasing SE. Atropine 0.01% controlled myopia more effectively in children with higher myopia, who were delivered naturally, and whose mothers had no genetic background of myopia.
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影响因子：
8.1
作者：
Zadnik K;Sinnott LT;Cotter SA;Jones-Jordan LA;Kleinstein RN;Manny RE;Twelker JD;Mutti DO;Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group
通讯作者：
Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group
影响因子：
4.2
作者：
Chia, Audrey;Chua, Wei-Han;Tan, Donald
通讯作者：
Tan, Donald
影响因子：
7.2
作者：
Zhang, Jun;Liu, Yinghui;Li, Zhu
通讯作者：
Li, Zhu
影响因子：
1.4
作者：
Zadnik, K
通讯作者：
Zadnik, K
影响因子：
2.7
作者：
Zhang, Xiaoyu;Qu, Xinhua;Zhou, Xingtao
通讯作者：
Zhou, Xingtao