EC-BLAST: a tool to automatically search and compare enzyme reactions.

EC-BLAST: a tool to automatically search and compare enzyme reactions.
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EC-Blast:一种自动搜索和比较酶反应的工具。

DOI:
10.1038/nmeth.2803
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发表时间:
2014-02
期刊:
影响因子:
48
通讯作者:
Thornton, Janet M.
Thornton, Janet M.
中科院分区:
生物学1区
文献类型:
--
作者:
Rahman, Syed Asad;Cuesta, Sergio Martinez;Furnham, Nicholas;Holliday, Gemma L.;Thornton, Janet M.

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EC-BLAST是一种用于在三个水平a)键变化、B)反应中心和c)反应结构相似性的酶反应之间进行定量相似性搜索的算法。它利用了所有已知的生化反应的键变化和反应模式的知识,这些反应来自每个反应的原子-原子映射(AAM)。这有可能改善已建立的酶分类系统,发现新的生化转化,改善酶功能的序列分配,以及酶的再工程。EC-BLAST URL:http://www.ebi.ac.uk/thornton-srv/software/rbl/
EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping (AAM) across each reaction. This has the potential to improve the established enzyme classification system, to find novel biochemical transformations, to improve the assignment of enzyme function to sequences, as well as for the re-engineering of enzymes. EC-BLAST URL: http://www.ebi.ac.uk/thornton-srv/software/rbl/
DOI: 10.1093/nar/gkr988
发表时间: 2012-01
影响因子: 14.9
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发表时间: 1982-01-01
期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH
影响因子: --
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通讯作者: HELMCHEN, G
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