Maternal methylmercury exposure through rice ingestion and child neurodevelopment in the first three years: a prospective cohort study in rural China.
Maternal methylmercury exposure through rice ingestion and child neurodevelopment in the first three years: a prospective cohort study in rural China.
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前三年母亲通过大米摄入甲基汞暴露和儿童神经发育：中国农村前瞻性队列研究
DOI：
10.1186/s12940-021-00732-z
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发表时间：
2021-04-28
期刊：
影响因子：
--
通讯作者：
Ouyang F
中科院分区：
文献类型：
--
作者：
Rothenberg SE;Korrick SA;Liu J;Nong Y;Nong H;Hong C;Trinh EP;Jiang X;Biasini FJ;Ouyang F
大米是甲基汞的重要膳食来源；然而，大米不含与鱼相同的有益营养成分。我们的主要目标是评估中国农村地区通过摄入大米而产前甲基汞暴露与儿童神经发育的关系。纳入符合条件的围产期妇女（n = 391），提供围产期头发样本，并使用贝利婴儿发育量表第二版评估儿童的神经发育在 12 个月（n = 264，68%）和 36 个月（n = 190，48%），包括心理发育指数（MDI）和精神运动发育指数（PDI）。使用线性混合模型进行重复测量，评估了妊娠晚期产前甲基汞暴露 [log2 母亲头发总汞 (THg)] 与儿童神经发育之间的关联。在调整后的模型中，母体毛发 THg 增加一倍，MDI 评分下降 1.3 分 [95% 置信区间 (CI)：− 2.6，− 0.14]，PDI 评分下降 1.2 分（95% CI：− 2.6，0.14）。总体而言，母亲头发 THg 和 MDI 评分之间的不利关联随着时间的推移而减弱。然而，随着时间的推移，主要照顾者是父母的儿童之间的关联是强大且稳定的。在研究跟踪期间，由祖父母抚养的儿童比例不断增加（12个月：9% vs 36个月：27%），这一趋势与父母从农村到城市打工有关。对于生活在中国农村的幼儿来说，产前甲基汞暴露的生物标志物与 12 至 36 个月大期间评估的认知功能下降有关。研究随访时间间隔内家庭结构的变化可能会影响儿童对产前甲基汞暴露的敏感性。在线版本包含可在 10.1186/s12940-021-00732-z 获取的补充材料。
Rice is an important dietary source for methylmercury; however, rice does not contain the same beneficial nutrients as fish. Our main objective was to assess associations of prenatal methylmercury exposure through rice ingestion with child neurodevelopment in rural China. Eligible peripartum women were enrolled (n = 391), provided peripartum hair samples, and children’s neurodevelopment was assessed at 12 months (n = 264, 68%) and 36 months (n = 190, 48%) using the Bayley Scales of Infant Development, 2nd Edition, including the Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI). Associations between prenatal methylmercury exposure during the third trimester [log2 maternal hair total mercury (THg)] and child’s neurodevelopment were assessed using linear mixed models for repeated measures. In adjusted models, a doubling in maternal hair THg corresponded to a 1.3-point decrement in the MDI score [95% confidence interval (CI): − 2.6, − 0.14], and a 1.2-point decrement in the PDI score (95% CI: − 2.6, 0.14). Overall, adverse associations between maternal hair THg and MDI scores attenuated over time. However, associations were robust and stable over time among children whose primary caregiver was their parent(s). During the study follow-up, an increasing proportion of children were raised by grandparents (12 months: 9% versus 36 months: 27%), a trend associated with rural-to-urban parental migration for work. For young children living in rural China, a biomarker of prenatal methylmercury exposure was associated with decrements in cognitive function assessed between 12 and 36 months of age. Changes in the family structure over the study follow-up time interval potentially impacted children’s sensitivity to prenatal methylmercury exposure. The online version contains supplementary material available at 10.1186/s12940-021-00732-z.
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