Characterization of gene expression changes over healthy term pregnancies.
Characterization of gene expression changes over healthy term pregnancies.
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DOI：
10.1371/journal.pone.0204228
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Smith AK
中科院分区：
文献类型：
--
作者：
Knight AK;Dunlop AL;Kilaru V;Cobb D;Corwin EJ;Conneely KN;Smith AK
在怀孕期间，妇女经历了许多生理变化，但迄今为止，有有限的已发表的数据，其特征伴随着怀孕期间基因表达的变化。这项研究试图描述健康妊娠妇女在妊娠过程中转录组的复杂性。受试者在妊娠早期（6-15周）和晚期（22-33周）提供静脉血样，用于在RNA提取前分离外周血单核细胞。对63名无并发症足月分娩的妇女进行了基因表达检查。我们评估了样本收集时妊娠周数与每种转录本表达之间的关联。在评估的16，311个转录本中，439个在Bonferroni校正后随妊娠发生变化，以解释多重比较。在怀孕期间表达增加的基因与氧气运输、免疫系统和宿主对细菌的反应有关。在健康的足月妊娠过程中转录组的变化的表征可能使基因的表达预测妊娠并发症或不良后果的鉴定。
During pregnancy, women experience numerous physiological changes but, to date, there is limited published data that characterize accompanying changes in gene expression over pregnancy. This study sought to characterize the complexity of the transcriptome over the course of pregnancy among women with healthy pregnancies. Subjects provided a venous blood sample during early (6–15 weeks) and late (22–33 weeks) pregnancy, which was used to isolate peripheral blood mononuclear cells prior to RNA extraction. Gene expression was examined for 63 women with uncomplicated, term deliveries. We evaluated the association between weeks gestation at sample collection and expression of each transcript. Of the 16,311 transcripts evaluated, 439 changed over pregnancy after a Bonferroni correction to account for multiple comparisons. Genes whose expression increased over pregnancy were associated with oxygen transport, the immune system, and host response to bacteria. Characterization of changes in the transcriptome over the course of healthy term pregnancies may enable the identification of genes whose expression predicts complications or adverse outcomes of pregnancy.
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DOI：
10.1002/9780470994955.ch2
发表时间：
2007-01-01
期刊：
HEART DISEASE IN PREGNANCY, 2ND EDITION
影响因子：
--
作者：
Silversides, Candice K.;Colman, Jack M.
通讯作者：
Colman, Jack M.
影响因子：
2
作者：
Saha D;Patgaonkar M;Shroff A;Ayyar K;Bashir T;Reddy KV
通讯作者：
Reddy KV
影响因子：
3.1
作者：
Jwa SC;Fujiwara T;Yamanobe Y;Kozuka K;Sago H
通讯作者：
Sago H
影响因子：
7.4
作者：
Butcher, Joshua T.;Johnson, Tyler;Beers, Jody;Columbus, Linda;Isakson, Brant E.
通讯作者：
Isakson, Brant E.
影响因子：
3.7
作者：
Han L;Liu X;Li H;Zou J;Yang Z;Han J;Huang W;Yu L;Zheng Y;Li L
通讯作者：
Li L