Changes in maternal hemoglobin during pregnancy and birth outcomes.
Changes in maternal hemoglobin during pregnancy and birth outcomes.
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DOI：
10.1186/s12884-015-0516-1
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发表时间：
2015-04-02
影响因子：
3.1
通讯作者：
Sago H
中科院分区：
文献类型：
--
作者：
Jwa SC;Fujiwara T;Yamanobe Y;Kozuka K;Sago H
孕期母体血红蛋白(Hb)水平与分娩结局的关系一直存在争议。怀孕期间Hb水平的变化可能会对分娩结果产生影响。这项研究的目的是调查从怀孕早期到中期或晚期Hb水平的变化是否与出生结局有关。参与者是2010年至2011年在国家儿童健康和发展中心分娩的怀孕34至41周的单身母亲(n = 1,986)。在三个时间点测量Hb水平：妊娠早期(16周)、中期(16-27周)和晚期(28-36周)。通过多元回归，调整母婴协变量，评估从妊娠早期到中期或晚期Hb水平的变化与出生结果(出生体重、出生体重Z分数、胎盘重量和胎盘比率)之间的关系。从妊娠早期到中期或晚期，Hb水平的较小下降与较低的出生体重、出生体重Z评分、胎盘重量和胎盘比率显著相关。与从妊娠早期到妊娠晚期的中期减少的妇女相比，减少最少的妇女分娩低出生体重(LBW)(调整后的优势比[AOR]，2.0；95%可信区间[CI]，1.3-3.1)和小于胎龄(SGA)(AOR，1.6；95%CI，1.04-2.3)的风险显著增加，而减少最大的妇女分娩SGA的风险显著降低(AOR，0.38；95%CI，0.23-0.65)，但高胎盘比率的风险增加(AOR，1.7；95%CI，1.2-2.5)。从妊娠早期到妊娠中期或晚期的Hb变化与出生体重、胎盘重量和胎盘比率呈负相关。
The relationship between maternal hemoglobin (Hb) levels during pregnancy and birth outcomes has been controversial. Changes in Hb level during pregnancy may have an impact on birth outcomes. This study aimed to investigate whether changes in Hb levels from early to mid- or late pregnancy is associated with birth outcomes. Participants were singleton mothers who delivered at the National Center for Child Health and Development between 34 and 41 weeks of gestation in 2010 and 2011 (n = 1,986). Hb levels were measured at three time points: early (<16 weeks), mid- (16–27 weeks), and late (28–36 weeks) pregnancy. Associations between changes in Hb levels from early to mid- or late pregnancy and birth outcomes (birth weight, Z-score of birth weight, placental weight, and placental ratio) were assessed by multiple regression, adjusting for maternal and fetal covariates. A smaller reduction in Hb levels from early to mid- or late pregnancy was significantly associated with lower birth weight, Z-score of birth weight, placental weight, and placental ratio. Compared to women with an intermediate reduction from early to late pregnancy, women with the least reduction had a significantly increased risk of delivering low birth weight (LBW) (adjusted odds ratio [aOR], 2.0; 95% confidence interval [CI], 1.3-3.1) and small-for-gestational-age (SGA) (aOR, 1.6; 95% CI, 1.04-2.3) infants, while women with the greatest reduction had a significantly decreased risk of delivering SGA (aOR, 0.38; 95% CI, 0.23-0.65) infants, but an increased risk of high placental ratio (aOR, 1.7; 95% CI, 1.2-2.5). Hb changes from early to mid- or late pregnancy were inversely associated with birth weight, placental weight, and placental ratio.
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影响因子：
7.1
作者：
SCHOLL, TO;HEDIGER, ML;SHEARER, JW
通讯作者：
SHEARER, JW
影响因子：
6.3
作者：
Hämäläinen, H;Hakkarainen, K;Heinonen, S
通讯作者：
Heinonen, S
DOI：
10.3109/14767058.2014.961006
发表时间：
2015-01-01
影响因子：
1.8
作者：
Cordina, Mark;Bhatti, Sadia;Kametas, Nikos A.
通讯作者：
Kametas, Nikos A.
DOI：
10.3109/14767058.2014.979149
发表时间：
2015-01-01
影响因子：
1.8
作者：
Bakacak, Murat;Avci, Fazil;Bakacak, Zeyneb
通讯作者：
Bakacak, Zeyneb
DOI：
10.5402/2012/368571
发表时间：
2012
期刊：
ISRN obstetrics and gynecology
影响因子：
--
作者：
Gonzales GF;Tapia V;Fort AL
通讯作者：
Fort AL