Compression of the vascular wall to create a friction fit in a vascular anastomotic coupler.
Compression of the vascular wall to create a friction fit in a vascular anastomotic coupler.
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DOI：
10.1016/j.jmbbm.2021.104681
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发表时间：
2021-11
影响因子：
3.9
通讯作者：
Agarwal J
中科院分区：
文献类型：
--
作者：
Nelson J;Patel D;Sant HJ;Shea J;Gale BK;Agarwal J
先前报道的微血管耦合器显示出有效地产生血管闭塞，但是对于实际临床使用来说太大。为了安全地减小耦合器尺寸，需要更好地了解某些故障模式。耦合器部分地通过压缩两个同心环之间的血管壁来起作用，从而产生将装置锚定到血管的摩擦配合。这项工作研究了血管壁压缩和产生的摩擦配合强度之间的关系，以确保减小耦合器尺寸不会过度增加这种摩擦配合可能失败的风险。将血管壁压缩至规定的应变，并测量克服所产生的摩擦所需的张力。使用各种血管类型（猪颈总动脉、脾动脉和颈静脉）在一定范围的压缩应变（55 - 95%）下进行实验，并使用PEEK或HDPE压缩血管。张力以5g/min的速率增加或保持恒定24小时。对于逐步增加的力的实验，在失败的力通过幂函数与压缩应变变化。在70%压缩下，PEEK产生的摩擦配合比HDPE强4.6倍，颈总动脉和脾动脉产生的配合分别比颈静脉强1.8倍和1.3倍。对于施加张力24小时的实验，需要低得多的力来克服摩擦。将这些结果与耦合器原型中的摩擦配合失效进行比较，发现原型在其他测试条件下仅在导致血管滑动所需的力的30%处失效。这些结果用于开发一个模型，该模型可预测通过血管滑动导致器械失效的概率（一种设计，小于先前报告的设计，估计在最大体内轴向应力下失效的概率为500次/500次，潜在安全风险水平）。
A previously reported microvascular coupler was shown to effectively create vascular anastomoses, but was too large for practical clinical use. To safely reduce coupler size, certain failure modes needed to be better understood. The coupler functions, in part, by compressing the vessel wall between two concentric rings, creating a friction fit that anchors the device to the vessel. This work investigates the relationship between vessel wall compression and resulting friction fit strength to ensure reducing coupler size will not unduly increase the risk that this friction fit might fail. Vascular walls were compressed to a specified strain and the tensile force required to overcome the resulting friction was measured. Experiments were conducted with various vessel types (Porcine common carotid artery, splenic artery, and jugular vein), across a range of compressive strains (55 – 95%), and by using either PEEK or HDPE to compress the vessel. Tensile force was increased at a rate of 5 g/min or held constant for 24 hrs. For experiments with incrementally increasing force, the force at failure varied with compressive strain via a power function. At 70% compression, PEEK produced 4.6 times stronger friction fits than HDPE, and common carotid arteries and splenic arteries produced 1.8 and 1.3 times stronger fits than jugular veins respectively. For experiments where tensile force was applied for 24 hrs, much lower forces were required to overcome friction. These results were compared to friction fit failure in a coupler prototype and it was found that the prototypes failed at just 30% of the force required to cause vessel slip under the other test conditions. These results were used to develop a model that predicts the probability of device failure via vessel slipping (one design, smaller than previously reported, was estimated to fail at maximum in vivo axial stress once in 500 anastomoses, a potentially safe level of risk).
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影响因子：
3.5
作者：
Jadidi, Majid;Desyatova, Anastasia;Kamenskiy, Alexey
通讯作者：
Kamenskiy, Alexey
DOI：
10.1016/s0967-2109(01)00087-4
发表时间：
2001-12-01
期刊：
CARDIOVASCULAR SURGERY
影响因子：
--
作者：
Kirsch, WM;Gupta, S;Zhu, YH
通讯作者：
Zhu, YH
影响因子：
0.9
作者：
Li, Huizhong;Agarwal, Jay;Gale, Bruce K.
通讯作者：
Gale, Bruce K.
影响因子：
0.9
作者：
Li, Huizhong;Gehrke, Cody;Agarwal, Jay
通讯作者：
Agarwal, Jay
DOI：
10.3109/02844318109103422
发表时间：
1981-01-01
影响因子：
--
作者：
LIDMAN, D;DANIEL, RK
通讯作者：
DANIEL, RK