Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field.
Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field.
复制标题
DOI：
10.1093/cercor/bhab007
复制
发表时间：
2021-06-10
期刊：
影响因子：
--
通讯作者：
Thiele A
中科院分区：
文献类型：
--
作者：
Dasilva M;Brandt C;Alwin Gieselmann M;Distler C;Thiele A
由额叶皮层控制的自上而下的注意是认知操作的关键组成部分。不同的神经递质和神经调质如何灵活地改变细胞和网络与注意力需求的相互作用仍然知之甚少。虽然乙酰胆碱和多巴胺是关键参与，多巴胺能受体已被提出发挥重要作用。为了了解它们对注意信号的贡献，我们研究了雄性猕猴额叶眼区（FEF）中的离子型神经递质受体如何对不同细胞类型中的神经元兴奋性和注意控制信号做出贡献。宽峰细胞和窄峰细胞都需要N-甲基-D-天冬氨酸和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体激活以获得正常兴奋性，从而影响持续或刺激驱动的活动。然而，注意力控制信号并不依赖于广泛或狭窄的尖峰细胞中的两种受体类型。使用基于尖峰波形和尖峰特征的聚类分析将细胞类型进一步细分为不同的功能类型并没有改变结论。这可以通过一个模型来解释，其中特定离子型受体的局部阻断通过细胞嵌入大规模网络来补偿。它将FEF中的多巴胺能系统与胆碱能系统分开，并表明兴奋性的降低不足以引起注意力控制信号的减少。
Top-down attention, controlled by frontal cortical areas, is a key component of cognitive operations. How different neurotransmitters and neuromodulators flexibly change the cellular and network interactions with attention demands remains poorly understood. While acetylcholine and dopamine are critically involved, glutamatergic receptors have been proposed to play important roles. To understand their contribution to attentional signals, we investigated how ionotropic glutamatergic receptors in the frontal eye field (FEF) of male macaques contribute to neuronal excitability and attentional control signals in different cell types. Broad-spiking and narrow-spiking cells both required N-methyl-D-aspartic acid and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation for normal excitability, thereby affecting ongoing or stimulus-driven activity. However, attentional control signals were not dependent on either glutamatergic receptor type in broad- or narrow-spiking cells. A further subdivision of cell types into different functional types using cluster-analysis based on spike waveforms and spiking characteristics did not change the conclusions. This can be explained by a model where local blockade of specific ionotropic receptors is compensated by cell embedding in large-scale networks. It sets the glutamatergic system apart from the cholinergic system in FEF and demonstrates that a reduction in excitability is not sufficient to induce a reduction in attentional control signals.
登录
查看更多内容
DOI：
10.1126/science.1171402
发表时间：
2009-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gregoriou GG;Gotts SJ;Zhou H;Desimone R
通讯作者：
Desimone R
影响因子：
25
作者：
Goris, Robbe L. T.;Movshon, J. Anthony;Simoncelli, Eero P.
通讯作者：
Simoncelli, Eero P.
影响因子：
25
作者：
Gregoriou, Georgia G.;Rossi, Andrew F.;Ungerleider, Leslie G.;Desimone, Robert
通讯作者：
Desimone, Robert
影响因子：
16.2
作者：
Herrero JL;Gieselmann MA;Sanayei M;Thiele A
通讯作者：
Thiele A
影响因子：
64.8
作者：
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者：
Thiele, A.