Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery.
Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery.
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DOI：
10.3390/nano11010173
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发表时间：
2021-01-12
期刊：
影响因子：
--
通讯作者：
Biswal MR
中科院分区：
文献类型：
--
作者：
Khiev D;Mohamed ZA;Vichare R;Paulson R;Bhatia S;Mohapatra S;Lobo GP;Valapala M;Kerur N;Passaglia CL;Mohapatra SS;Biswal MR
眼部疾病会使视力恶化到失明的程度，从而对个人的日常生活产生重大影响。由于血液-视网膜屏障给药过程中的一些限制，传统疗法无法对所有眼部疾病提供绝对治疗，这是一个重大的临床挑战。随着最近的发展，大量的出版物强调了在治疗眼部疾病中需要基于纳米技术的药物输送系统。纳米技术的工具提供了几个基本的优势，包括持续的药物释放和特定的组织靶向。此外，全面的体外和体内研究表明，纳米颗粒可以更好地通过眼屏障吸收。纳米颗粒可以克服血液-视网膜屏障，从而增加眼部穿透性，提高药物的生物利用度。本文就有机纳米粒子和无机纳米粒子在眼科领域的应用作一综述。我们强调了临床试验中潜在的纳米配方以及已经成为商业现实的产品。
Ocular diseases can deteriorate vision to the point of blindness and thus can have a major impact on the daily life of an individual. Conventional therapies are unable to provide absolute therapy for all ocular diseases due to the several limitations during drug delivery across the blood-retinal barrier, making it a major clinical challenge. With recent developments, the vast number of publications undergird the need for nanotechnology-based drug delivery systems in treating ocular diseases. The tool of nanotechnology provides several essential advantages, including sustained drug release and specific tissue targeting. Additionally, comprehensive in vitro and in vivo studies have suggested a better uptake of nanoparticles across ocular barriers. Nanoparticles can overcome the blood-retinal barrier and consequently increase ocular penetration and improve the bioavailability of the drug. In this review, we aim to summarize the development of organic and inorganic nanoparticles for ophthalmic applications. We highlight the potential nanoformulations in clinical trials as well as the products that have become a commercial reality.
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