Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants.
Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants.
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DOI：
10.3390/nu9080817
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发表时间：
2017-07-28
期刊：
影响因子：
5.9
通讯作者：
Lönnerdal B
中科院分区：
文献类型：
--
作者：
Demmelmair H;Prell C;Timby N;Lönnerdal B
乳蛋白的主要功能是为母乳喂养的婴儿提供必需和非必需氨基酸。此外，母乳喂养的婴儿可能受益于乳蛋白的生物活性，这些生物活性在消化阶段在肠道中通过吸收完整的蛋白质或衍生肽而表现出来。乳铁蛋白、骨桥蛋白和乳脂球膜蛋白/脂质直到最近才被大量纳入婴儿配方奶粉中，体外实验和动物模型为其生物活性提供了令人信服的证据基础，有助于保护婴儿免受病原体侵害，改善营养吸收，支持免疫系统的发育，并为最佳神经发育提供成分。从牛奶中提取这些化合物的技术已经成熟，而且这些牛化合物在人体内也表现出生物活性。含有乳铁蛋白、骨桥蛋白或乳脂球膜的实验性婴儿配方奶粉的随机临床试验已经为临床益处提供了一些证据。本综述旨在比较实验室和动物实验的结果与临床研究的结果。基础科学有充分的理由，临床研究也有令人鼓舞的结果，证明乳铁蛋白、骨桥蛋白和由蛋白质和脂质组成的乳脂球膜复合物的有益作用。理想情况下，进一步的研究应该有足够的动力来调查对健康足月婴儿临床相关终点的影响。
The provision of essential and non-essential amino acids for breast-fed infants is the major function of milk proteins. In addition, breast-fed infants might benefit from bioactivities of milk proteins, which are exhibited in the intestine during the digestive phase and by absorption of intact proteins or derived peptides. For lactoferrin, osteopontin and milk fat globule membrane proteins/lipids, which have not until recently been included in substantial amounts in infant formulas, in vitro experiments and animal models provide a convincing base of evidence for bioactivities, which contribute to the protection of the infant from pathogens, improve nutrient absorption, support the development of the immune system and provide components for optimal neurodevelopment. Technologies have become available to obtain these compounds from cow´s milk and the bovine compounds also exhibit bioactivities in humans. Randomized clinical trials with experimental infant formulas incorporating lactoferrin, osteopontin, or milk fat globule membranes have already provided some evidence for clinical benefits. This review aims to compare findings from laboratory and animal experiments with outcomes of clinical studies. There is good justification from basic science and there are promising results from clinical studies for beneficial effects of lactoferrin, osteopontin and the milk fat globule membrane complex of proteins and lipids. Further studies should ideally be adequately powered to investigate effects on clinically relevant endpoints in healthy term infants.
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影响因子：
7.1
作者：
Adkins, Y;Lönnerdal, B
通讯作者：
Lönnerdal, B
DOI：
10.1097/mpg.0b013e3181e07f0a
发表时间：
2010-09-01
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影响因子：
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作者：
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影响因子：
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