Vasopressin antagonists for patients with acute heart failure: interpreting new clinical and translational data.

Vasopressin antagonists for patients with acute heart failure: interpreting new clinical and translational data.
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加压素拮抗剂治疗急性心力衰竭患者:解释新的临床和转化数据。

DOI:
10.1038/clpt.2013.240
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发表时间:
2014
影响因子:
6.7
通讯作者:
Cheung,JY
Cheung,JY
中科院分区:
医学2区
文献类型:
--
作者:
Feldman,AM;Hamad,E;Tsai,EJ;Zhu,W;Tilley,DG;Alvarez,R;Cheung,JY

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精氨酸加压素(AVP)水平升高与心力衰竭(HF)患者预后不良和低钠血症的发生有关。这一观察结果导致开发用于治疗HF患者的AVP受体拮抗剂。尽管AVP受体拮抗剂可增加血清钠,但其在HF患者中的总体获益充其量是适度的,最近的数据引起了对其在急性HF和低血清钠患者中安全性的担忧。
Elevated levels of arginine vasopressin (AVP) are associated with a worse prognosis and the development of hyponatremia in patients with heart failure (HF). This observation led to the development of AVP receptor antagonists for the treatment of HF patients. Although AVP receptor antagonists increase serum sodium, their overall benefits in patients with HF have been at best modest, and recent data raise concerns about their safety in patients with acute HF and low serum sodium.
ATP依赖性限制性内切酶
DOI: 10.1101/087969155.14.85
发表时间: 1982
期刊: Cold Spring Harbor Monograph Archive
影响因子: --
作者:
T. Bickle
通讯作者: T. Bickle
DOI: 10.1016/0003-2697(85)90533-0
发表时间: 1985-01-01
影响因子: 2.9
作者:
HUBSCHER, U;PEDRALINOY, G;SPADARI, S
通讯作者: SPADARI, S