Complexity of Frontal Cortex fNIRS Can Support Alzheimer Disease Diagnosis in Memory and Visuo-Spatial Tests.
Complexity of Frontal Cortex fNIRS Can Support Alzheimer Disease Diagnosis in Memory and Visuo-Spatial Tests.
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DOI：
10.3390/e21010026
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Merla A
中科院分区：
文献类型：
--
作者：
Perpetuini D;Chiarelli AM;Cardone D;Filippini C;Bucco R;Zito M;Merla A
Decline in visuo-spatial skills and memory failures are considered symptoms of Alzheimer’s Disease (AD) and they can be assessed at early stages employing clinical tests. However, performance in a single test is generally not indicative of AD. Functional neuroimaging, such as functional Near Infrared Spectroscopy (fNIRS), may be employed during these tests in an ecological setting to support diagnosis. Indeed, neuroimaging should not alter clinical practice allowing free doctor-patient interaction. However, block-designed paradigms, necessary for standard functional neuroimaging analysis, require tests adaptation. Novel signal analysis procedures (e.g., signal complexity evaluation) may be useful to establish brain signals differences without altering experimental conditions. In this study, we estimated fNIRS complexity (through Sample Entropy metric) in frontal cortex of early AD and controls during three tests that assess visuo-spatial and short-term-memory abilities (Clock Drawing Test, Digit Span Test, Corsi Block Tapping Test). A channel-based analysis of fNIRS complexity during the tests revealed AD-induced changes. Importantly, a multivariate analysis of fNIRS complexity provided good specificity and sensitivity to AD. This outcome was compared to cognitive tests performances that were predictive of AD in only one test. Our results demonstrated the capabilities of fNIRS and complexity metric to support early AD diagnosis.
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同时功能性近红外光谱和脑电图，以监测人脑活动和氧合的监测：综述。
影响因子：
5.3
作者：
Chiarelli AM;Zappasodi F;Di Pompeo F;Merla A
通讯作者：
Merla A
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
DOI：
10.1016/s0926-6410(97)00016-5
发表时间：
1997-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
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Strik, WK
影响因子：
3.2
作者：
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Poza, J
影响因子：
3.2
作者：
Escudero, J.;Abasolo, D.;Lopez, M.
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Lopez, M.