Alcohol, cytokines, and estrogen in the control of bone remodeling.
Alcohol, cytokines, and estrogen in the control of bone remodeling.
复制标题
酒精、细胞因子和雌激素控制骨重塑。
DOI：
10.1111/j.1530-0277.1997.tb03780.x
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
R. Kimble
中科院分区：
文献类型：
--
作者：
R. Kimble
酒精已被确定为骨质疏松症发展的危险因素。长期酗酒已被证明会降低骨量，增加骨折的发生率。虽然酒精影响骨代谢的确切机制尚不清楚，但它可能是对骨细胞直接和间接影响的组合。酒精有可能通过影响性腺激素和分泌细胞因子间接改变骨代谢，这些细胞因子是绝经后骨质疏松症的关键因素。本文总结的数据表明，白细胞介素-1和肿瘤坏死因子在雌激素缺乏引起的骨丢失中起着直接的因果作用。此外，引用的研究表明，这些相同的细胞因子在酒精诱导的肝病中产生，有可能增加绝经后妇女和男性患者的骨丢失。虽然还没有数据直接支持细胞因子在酒精消耗引起的骨丢失中的作用，但本文提出的研究旨在刺激对酒精，雌激素和细胞因子在骨质疏松性骨丢失中的作用的进一步研究。
Alcohol has been identified as a risk factor for the development of osteoporosis. Chronic alcohol abuse has been shown to decrease bone mass and increase the incidence of fractures. Although the exact mechanism by which alcohol influences bone metabolism is not clear, it is likely a combination of both direct and indirect effects on bone cells. Alcohol has the potential to alter bone metabolism indirectly through its effects on gonadal hormones and through the secretion of cytokines shown to be critical factors in postmenopausal osteoporosis. Data are summarized here demonstrating that interleukin-1 and tumor necrosis factor play a direct causal role in the bone loss due to estrogen deficiency. In addition, studies are cited showing that these same cytokines are produced in alcohol-induced liver disease with the potential to enhance bone loss in post-menopausal women and in male patients. Although there are not yet data directly supporting the role of cytokines in bone loss due to alcohol consumption, the studies presented herein are intended to stimulate further research on the role of alcohol, estrogen, and cytokines in osteoporotic bone loss.
登录
查看更多内容
影响因子：
15.9
作者：
DELAMATA, J;UY, HL;ROODMAN, GD
通讯作者：
ROODMAN, GD
影响因子：
4.8
作者：
R. Kimble;A. Matayoshi;J. Vannice;V. Kung;C. Williams;R. Pacifici
通讯作者：
R. Kimble;A. Matayoshi;J. Vannice;V. Kung;C. Williams;R. Pacifici
影响因子：
20.3
作者：
E. Canalis
通讯作者：
E. Canalis
影响因子：
15.9
作者：
KITAZAWA, R;KIMBLE, RB;PACIFICI, R
通讯作者：
PACIFICI, R
影响因子：
5.8
作者：
FINKELSTEIN, JS;KLIBANSKI, A;CROWLEY, WF
通讯作者：
CROWLEY, WF