The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions.
The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions.
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DOI：
10.1038/sj.bjc.6602253
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发表时间：
2004-12-13
影响因子：
8.8
通讯作者：
Cuzick, J
中科院分区：
文献类型：
--
作者：
Terry, G;Ho, L;Londesborough, P;Cross, P;Lopes, A;Monaghan, J;Cuzick, J
对83例宫颈癌和74例宫颈上皮内瘤变1级病变评估了高危型人乳头瘤病毒的存在、3号染色体杂合性缺失以及脆性组氨酸三联体基因表达，将其作为癌症和宫颈上皮内瘤变进展的潜在标志物。人乳头瘤病毒16型是癌症血管受累的一个指标。杂合性缺失，尤其是脆性组氨酸三联体基因内含子5的杂合性缺失，是高级别肿瘤、更大肿瘤深度和淋巴结受累的一个指标。脆性组氨酸三联体基因表达异常在疾病进展风险增加的宫颈上皮内瘤变1级病变中更为常见。
The presence of high-risk human papillomavirus, loss of heterozygosity on chromosome 3p and fragile histidine triad gene expression were assessed as potential markers of cancer and CIN progression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. Human papillomavirus type 16 was an indicator of vascular involvement in cancers. Loss of heterozygosity, especially in the fragile histidine triad gene intron 5, was an indicator of high-grade tumours, greater tumour depth and lymph node involvement. Abnormal fragile histidine triad gene expression was more frequent in cervical intraepithelial neoplasia grade 1 lesions with increased risk of disease progression.
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影响因子：
8.8
作者：
Cuzick, J;Terry, G;Duncan, I
通讯作者：
Duncan, I
影响因子：
64.8
作者：
NAYLOR, SL;JOHNSON, BE;SAKAGUCHI, AY
通讯作者：
SAKAGUCHI, AY
影响因子：
9.7
作者：
Chung, TKH;Cheung, TH;Wong, YF
通讯作者：
Wong, YF
DOI：
10.1073/pnas.062030799
发表时间：
2002-03-19
影响因子：
11.1
作者：
Roz, L;Gramegna, M;Sozzi, G
通讯作者：
Sozzi, G
影响因子：
6.2
作者：
Acevedo, CM;Henríquez, M;Chuaqui, RF
通讯作者：
Chuaqui, RF