Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods.
Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods.
复制标题
鉴定了八种合成大麻素，包括使用DART-TOF-MS和LC-QTOF-MS作为非目标筛选方法的捕获草药产品中的5F-AKB48。
DOI：
10.1111/1556-4029.13367
复制
发表时间：
2017-09
影响因子：
1.6
通讯作者：
Grabenauer M
中科院分区：
文献类型：
--
作者：
Moore KN;Garvin D;Thomas BF;Grabenauer M
合成大麻素被喷洒在植物材料上，并因其大麻般的效果而被烟熏。秘密制造商通过制造密切相关的类似物来修改合成大麻素的结构。法医实验室的任务是检测这些类似化合物，但有针对性的分析方法往往受到结构修饰的阻碍。在这里，直接分析在真实的时间耦合到准确的质量飞行时间质谱（DART-TOF-MS）结合液相色谱四重飞行时间质谱（LC-QTOF-MS）分别作为一种筛选和非靶向确认方法。使用两种方法运行草药材料的甲醇提取物。通过将碎片模式、准确质量和保留时间与可用参考标准进行比较，评价了四种不同草药产品的光谱数据。产品中鉴定出JWH-018、JWH-019、AM 2201、JWH-122、5 F-AKB48、AKB48-N-（4-戊烯基）类似物、UR 144和XLR 11。结果表明，DART-TOF-MS为快速筛选草药产品中合成大麻素的存在和鉴定提供了一种有用的方法。
Synthetic cannabinoids are sprayed onto plant material and smoked for their marijuana-like effects. Clandestine manufacturers modify synthetic cannabinoid structures by creating closely related analogs. Forensic laboratories are tasked with detection of these analog compounds, but targeted analytical methods are often thwarted by the structural modifications. Here, direct analysis in real time coupled to accurate mass time-of-flight mass spectrometry (DART-TOF-MS) in combination with liquid chromatography quadruple time-of-flight mass spectrometry (LC-QTOF-MS) are presented as a screening and nontargeted confirmation method, respectively. Methanol extracts of herbal material were run using both methods. Spectral data from four different herbal products were evaluated by comparing fragmentation pattern, accurate mass and retention time to available reference standards. JWH-018, JWH-019, AM2201, JWH-122, 5F-AKB48, AKB48-N-(4-pentenyl) analog, UR144, and XLR11 were identified in the products. Results demonstrate that DART-TOF-MS affords a useful approach for rapid screening of herbal products for the presence and identification of synthetic cannabinoids.
登录
查看更多内容
影响因子：
4.5
作者：
Gandhi, Adarsh S.;Zhu, Mingshe;Huestis, Marilyn A.
通讯作者：
Huestis, Marilyn A.
影响因子：
1.5
作者：
Habala, Ladislav;Valentova, Jindra;Devinsky, Ferdinand
通讯作者：
Devinsky, Ferdinand
影响因子：
2.2
作者：
Lindigkeit, Rainer;Boehme, Anja;Beuerle, Till
通讯作者：
Beuerle, Till
使用高分辨率的质谱和质谱滤波来分析合成大麻素，对设计师药物的非目标筛查的影响。
影响因子：
7.4
作者：
Grabenauer M;Krol WL;Wiley JL;Thomas BF
通讯作者：
Thomas BF
影响因子：
2
作者：
Hillebrand, Jennifer;Olszewski, Deborah;Sedefov, Roumen
通讯作者：
Sedefov, Roumen