Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis.
Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis.
复制标题
免疫系统中细胞与细胞之间的啃咬：朋友还是敌人？
DOI：
10.3389/fimmu.2022.791006
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发表时间：
2022
影响因子：
7.3
通讯作者：
Shen J
中科院分区：
文献类型：
--
作者：
Zhao S;Zhang L;Xiang S;Hu Y;Wu Z;Shen J
当一个细胞接触并快速蚕食另一个细胞时，就会发生 Trogocytosis，其特征是活细胞之间的接触以及具有功能完整性的膜碎片的快速转移。许多免疫细胞参与这个过程，如T细胞、B细胞、NK细胞、APC。转移的膜分子包括MHC分子、共刺激分子、受体、抗原等。越来越多的研究表明，trogocytosis在免疫系统和相关疾病的发生中发挥着重要作用。因此，吞噬作用对于免疫系统来说是朋友还是敌人还是令人费解，其背后的确切机制尚未完全阐明。在这里，我们提供了关于吞噬细胞作用和免疫系统之间的联系的已获得研究结果的综合视图。
Trogocytosis occurs when one cell contacts and quickly nibbles another cell and is characterized by contact between living cells and rapid transfer of membrane fragments with functional integrity. Many immune cells are involved in this process, such as T cells, B cells, NK cells, APCs. The transferred membrane molecules including MHC molecules, costimulatory molecules, receptors, antigens, etc. An increasing number of studies have shown that trogocytosis plays an important role in the immune system and the occurrence of relevant diseases. Thus, whether trogocytosis is a friend or foe of the immune system is puzzling, and the precise mechanism underlying it has not yet been fully elucidated. Here, we provide an integrated view of the acquired findings on the connections between trogocytosis and the immune system.
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影响因子：
3.7
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