Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
复制标题
丹酚酸 B 通过诱导自噬促进大鼠随机型皮瓣的存活
DOI：
10.3389/fphar.2018.01178
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发表时间：
2018
影响因子：
5.6
通讯作者：
Zhou K
中科院分区：
文献类型：
--
作者：
Lin J;Lin R;Li S;Wu H;Ding J;Xiang G;Li S;Wang Y;Lin D;Gao W;Kong J;Xu H;Zhou K
随意型皮瓣移植是整形外科常用的一种方法。然而，皮瓣的远端部分经常由于缺血而坏死。本研究评价了丹参素B（Sal B）对皮瓣成活的影响，并探讨了其作用机制。7天后，Sal B改善了存活面积，减少了组织水肿，并增加了皮瓣中的微血管数量，而自噬抑制剂（3-甲基腺嘌呤）逆转了Sal B诱导的皮瓣活力增加。此外，Sal B刺激血管生成，抑制细胞凋亡，减少氧化应激，并上调缺血区域的自噬。此外，Sal B对血管生成、细胞凋亡和氧化应激的影响可通过自噬抑制逆转。总的来说，我们的研究结果表明，Sal B具有促血管生成，抗凋亡，抗氧化应激的作用，通过刺激自噬，这提高了随机模式皮瓣的生存。
Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. Sal B improved the survival area, reduced tissue edema, and increased the number of microvessels in skin flaps after 7 days, whereas an autophagy inhibitor (3-methyladenine) reversed the Sal B-induced increase in flap viability. In addition, Sal B stimulated angiogenesis, inhibited apoptosis, reduced oxidative stress, and upregulated autophagy in areas of ischemia. Moreover, the effects of Sal B on angiogenesis, apoptosis, and oxidative stress were reversed by autophagy inhibition. Overall, our findings suggest that Sal B has pro-angiogenesis, anti-apoptosis, and anti-oxidative stress effects by stimulating autophagy, which enhances the survival of random-pattern skin flaps.
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影响因子：
9.8
作者：
Nowak-Sliwinska P;Alitalo K;Allen E;Anisimov A;Aplin AC;Auerbach R;Augustin HG;Bates DO;van Beijnum JR;Bender RHF;Bergers G;Bikfalvi A;Bischoff J;Böck BC;Brooks PC;Bussolino F;Cakir B;Carmeliet P;Castranova D;Cimpean AM;Cleaver O;Coukos G;Davis GE;De Palma M;Dimberg A;Dings RPM;Djonov V;Dudley AC;Dufton NP;Fendt SM;Ferrara N;Fruttiger M;Fukumura D;Ghesquière B;Gong Y;Griffin RJ;Harris AL;Hughes CCW;Hultgren NW;Iruela-Arispe ML;Irving M;Jain RK;Kalluri R;Kalucka J;Kerbel RS;Kitajewski J;Klaassen I;Kleinmann HK;Koolwijk P;Kuczynski E;Kwak BR;Marien K;Melero-Martin JM;Munn LL;Nicosia RF;Noel A;Nurro J;Olsson AK;Petrova TV;Pietras K;Pili R;Pollard JW;Post MJ;Quax PHA;Rabinovich GA;Raica M;Randi AM;Ribatti D;Ruegg C;Schlingemann RO;Schulte-Merker S;Smith LEH;Song JW;Stacker SA;Stalin J;Stratman AN;Van de Velde M;van Hinsbergh VWM;Vermeulen PB;Waltenberger J;Weinstein BM;Xin H;Yetkin-Arik B;Yla-Herttuala S;Yoder MC;Griffioen AW
通讯作者：
Griffioen AW
影响因子：
--
作者：
Li D;Wang J;Hou J;Fu J;Liu J;Lin R
通讯作者：
Lin R
影响因子：
13.3
作者：
Lopez de Figueroa, Paloma;Lotz, Martin K.;Blanco, Francisco J.;Carames, Beatriz
通讯作者：
Carames, Beatriz
影响因子：
2.5
作者：
Lee, W. -S.;Yoo, W. -H.;Chae, H. -J.
通讯作者：
Chae, H. -J.
影响因子：
13.6
作者：
Anet, Antony;Olakkaran, Shilpa;Puttaswamygowda, Gurushankara Hunasanahally
通讯作者：
Puttaswamygowda, Gurushankara Hunasanahally