Gene expression in the efferent ducts, epididymis, and vas deferens during embryonic development of the mouse.
Gene expression in the efferent ducts, epididymis, and vas deferens during embryonic development of the mouse.
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DOI：
10.1002/dvdy.22378
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发表时间：
2010-09
影响因子：
2.5
通讯作者：
Hinton, Barry T.
中科院分区：
文献类型：
--
作者：
Snyder, Elizabeth M.;Small, Christopher L.;Bomgardner, Daniela;Xu, Bingfang;Evanoff, Ryan;Griswold, Michael D.;Hinton, Barry T.
雄性生殖道的组织具有不同的形态特征，从高度卷曲到非卷曲。从胚胎第14.5天到出生后第1天，随着组织特异性形态的出现，产生了输出管、附睾和输精管的全球基因表达谱。同源异型盒基因的表达，组织特异性形态发育的潜在介质，进行了评估。20个同源异型盒基因被鉴定为组织富集、发育调节或两者兼而有之。此外，本体分析表明细胞粘附沿生殖道的长度被高度调节沿着。在三种组织之间具有可变表达的细胞粘附调节剂被鉴定，包括Alcam、各种钙粘蛋白和多种整合素。免疫荧光定位的细胞粘附调节剂POH4和CDH2表明，细胞粘附在上皮和间充质的附睾可能会改变整个发展。这些结果意味着细胞粘附可能以组织特异性方式进行调节，在建立每个组织的最终形态中起重要作用。
The tissues of the male reproductive tract are characterized by distinct morphologies, from highly coiled to un-coiled. Global gene expression profiles of efferent ducts, epididymis, and vas deferens were generated from embryonic day 14.5 to postnatal day 1 as tissue-specific morphologies emerge. Expression of homeobox genes, potential mediators of tissue-specific morphological development, was assessed. Twenty homeobox genes were identified as either tissue-enriched, developmentally regulated, or both. Additionally, ontology analysis demonstrated cell adhesion to be highly regulated along the length of the reproductive tract. Regulators of cell adhesion with variable expression between the three tissues were identified including Alcam, various cadherins, and multiple integrins. Immunofluorescence localization of the cell adhesion regulators POSTN and CDH2 demonstrated cell adhesion in the epithelium and mesenchyme of the epididymis may change throughout development. These results imply cell adhesion may be modulated in a tissue-specific manner, playing an important role in establishing each tissue’s final morphology.
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影响因子：
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