Plant-based solutions for veterinary immunotherapeutics and prophylactics.
Plant-based solutions for veterinary immunotherapeutics and prophylactics.
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DOI：
10.1186/s13567-014-0117-4
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发表时间：
2014-12-31
影响因子：
4.4
通讯作者：
Menassa R
中科院分区：
文献类型：
--
作者：
Kolotilin I;Topp E;Cox E;Devriendt B;Conrad U;Joensuu J;Stöger E;Warzecha H;McAllister T;Potter A;McLean MD;Hall JC;Menassa R
据世界卫生组织称，全世界病原体中抗生素耐药性的出现令人震惊地增加，已对我们治疗传染病的能力构成严重威胁。畜牧生产者广泛使用抗生素促进了新的耐药菌株的传播，其中一些菌株引起人畜共患病，这增加了人类食源性疾病的发生，给医疗保健系统造成了巨大的经济负担。此外，消费者对不使用抗生素生产的肉类/家禽/鱼类的偏好决定了当今的市场需求。因此，“同一个健康倡议”认为，人类需要减少抗生素的使用，转而采用替代的、改进的方法来控制疾病：疫苗接种和预防措施，这是不可避免的。除了专注于新型治疗分子的深入研究之外，这两种策略都严重依赖于具有成本效益、高效且可扩展的生产平台的可用性，这些平台将允许大批量生产疫苗、抗体和其他生物制药。在此背景下，基于植物的重组治疗蛋白生产平台比传统表达系统具有显着优势，包括缺乏动物病原体、生产成本低、周转和响应时间快以及快速、几乎无限的可扩展性。此外，由于干燥的叶子和种子可以在室温下长期保存而不会损失重组蛋白，因此植物表达系统有可能从可食用疫苗和预防剂的开发中带来丰厚的利益，因为这些疫苗和预防剂不需要“冷链”储存和运输，并且可以通过最少的加工进行大量施用。目前，多家生物技术公司已开发并采用基于植物的平台来商业化生产重组蛋白疗法。在这份手稿中，我们概述了牲畜免疫过程中的挑战以及当前旨在应对这些挑战的植物生物技术的发展。
An alarming increase in emergence of antibiotic resistance among pathogens worldwide has become a serious threat to our ability to treat infectious diseases according to the World Health Organization. Extensive use of antibiotics by livestock producers promotes the spread of new resistant strains, some of zoonotic concern, which increases food-borne illness in humans and causes significant economic burden on healthcare systems. Furthermore, consumer preferences for meat/poultry/fish produced without the use of antibiotics shape today’s market demand. So, it is viewed as inevitable by the One Health Initiative that humans need to reduce the use of antibiotics and turn to alternative, improved means to control disease: vaccination and prophylactics. Besides the intense research focused on novel therapeutic molecules, both these strategies rely heavily on the availability of cost-effective, efficient and scalable production platforms which will allow large-volume manufacturing for vaccines, antibodies and other biopharmaceuticals. Within this context, plant-based platforms for production of recombinant therapeutic proteins offer significant advantages over conventional expression systems, including lack of animal pathogens, low production costs, fast turnaround and response times and rapid, nearly-unlimited scalability. Also, because dried leaves and seeds can be stored at room temperature for lengthy periods without loss of recombinant proteins, plant expression systems have the potential to offer lucrative benefits from the development of edible vaccines and prophylactics, as these would not require “cold chain” storage and transportation, and could be administered in mass volumes with minimal processing. Several biotechnology companies currently have developed and adopted plant-based platforms for commercial production of recombinant protein therapeutics. In this manuscript, we outline the challenges in the process of livestock immunization as well as the current plant biotechnology developments aimed to address these challenges.
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影响因子：
5.9
作者：
Hurley WL;Theil PK
通讯作者：
Theil PK
影响因子：
5.5
作者：
Cummings JF;Guerrero ML;Moon JE;Waterman P;Nielsen RK;Jefferson S;Gross FL;Hancock K;Katz JM;Yusibov V;Fraunhofer USA Center for Molecular Biotechnology Study Group
通讯作者：
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影响因子：
13.8
作者：
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通讯作者：
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5.5
作者：
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通讯作者：
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影响因子：
5.5
作者：
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通讯作者：
Sadir, AM