Physical performance and radiographic and clinical vertebral fractures in older men.
Physical performance and radiographic and clinical vertebral fractures in older men.
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DOI：
10.1002/jbmr.2239
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发表时间：
2014-09
影响因子：
6.2
通讯作者：
Schousboe, John T.
中科院分区：
文献类型：
--
作者：
Cawthon, Peggy M.;Blackwell, Terri L.;Marshall, Lynn M.;Fink, Howard A.;Kado, Deborah M.;Ensrud, Kristine E.;Cauley, Jane A.;Black, Dennis;Orwoll, Eric S.;Cummings, Steven R.;Schousboe, John T.
在男性中，较差的身体表现与发生椎骨骨折的可能性之间的关系尚不清楚。使用来自MrOS研究的数据（N=5958），我们描述了基线体能[步行速度、握力、腿部力量、重复椅子站立、狭窄步行（动态平衡）]与影像学和临床椎体骨折发生率之间的相关性。在基线和平均4.6年后的随访中，使用侧位胸椎和腰椎X线片的半定量（SQ）评分对影像学椎体骨折进行评估。Logistic回归模型描述了体能与影像学椎体骨折事件（从基线到随访SQ等级变化≥1）之间的相关性。基线后每四个月，参与者自我报告骨折;临床椎骨骨折由基线研究X线片和社区获得的脊柱图像的集中放射科医生审查确认。比例风险回归模型的物理性能与临床椎骨骨折事件之间的关联。根据年龄、BMD（DXA）、临床中心、种族、吸烟、身高、体重、福尔斯史、活动水平和合并症调整多变量模型;将体能作为四分位数进行分析。在4332名有基线和重复X线片的男性中，192名（4.4%）有放射学椎骨骨折事件。除步行速度外，重复椅子站立、腿部力量、窄距离行走和握力的较差表现均与发生放射学椎骨骨折的风险增加分级相关（四分位数趋势p <0.001）。此外，与在所有检查中表现更好的男性相比，在三次或三次以上检查中表现最差的四分位数的男性发生放射学骨折的风险增加（OR：1.81，9% CI：1.33，2.45）。临床椎骨骨折（N=149/5，813，2.6%）与身体表现不一致。我们的结论是，较差的体力活动与老年男性发生影像学（而非临床）椎体骨折的风险增加有关。
In men, the association between poor physical performance and likelihood of incident vertebral fractures is unknown. Using data from the MrOS study (N=5958), we describe the association between baseline physical performance [walking speed, grip strength, leg power, repeat chair stands, narrow walk (dynamic balance)] and incidence of radiographic and clinical vertebral fractures. At baseline and follow-up an average of 4.6 years later, radiographic vertebral fractures were assessed using semi-quantitative (SQ) scoring on lateral thoracic and lumbar radiographs. Logistic regression modeled the association between physical performance and incident radiographic vertebral fractures (change in SQ grade≥1 from baseline to follow-up). Every four months after baseline, participants self-reported fractures; clinical vertebral fractures were confirmed by centralized radiologist review of the baseline study radiograph and community acquired spine images. Proportional hazards regression modeled the association between physical performance with incident clinical vertebral fractures. Multivariate models were adjusted for age, BMD (by DXA), clinical center, race, smoking, height, weight, history of falls, activity level and co-morbid medical conditions; physical performance was analyzed as quartiles. Of 4332 men with baseline and repeat radiographs, 192 (4.4%) had an incident radiographic vertebral fracture. With the exception of walking speed, poorer performance on repeat chair stands, leg power, narrow walk and grip strength were each associated in a graded manner with an increased risk of incident radiographic vertebral fracture (p for trend across quartiles <0.001). In addition, men with performance in the worst quartile on three or more exams had an increased risk of radiographic fracture (OR: 1.81, 9% CI: 1.33, 2.45) compared to men with better performance on all exams. Clinical vertebral fracture (N=149 of 5,813, 2.6%) was not consistently associated with physical performance. We conclude that poorer physical performance is associated with an increased risk of incident radiographic (but not clinical) vertebral fracture in older men.
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影响因子：
6.2
作者：
Burger, H;vanDaele, PLA;Pols, HAP
通讯作者：
Pols, HAP
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
DOI：
10.1002/jbmr.1969
发表时间：
2013-07
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
DiGirolamo DJ;Kiel DP;Esser KA
通讯作者：
Esser KA
影响因子：
6.2
作者：
Nevitt, MC;Cummings, SR;Cauley, JA
通讯作者：
Cauley, JA
影响因子：
5
作者：
Chan, Benjamin K. S.;Marshall, Lynn M.;Orwoll, Eric S.
通讯作者：
Orwoll, Eric S.