Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex.
Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex.
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DOI：
10.1186/1471-2202-12-115
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发表时间：
2011-11-15
期刊：
影响因子：
2.4
通讯作者：
Kawakami Y
中科院分区：
文献类型：
--
作者：
Onozawa K;Yagasaki Y;Izawa Y;Abe H;Kawakami Y
我们先前证实，机械伤害性刺激可在前额叶皮质(PFC)诱发伤害性放电。可以想象，PFC中记录的伤害性反应与疼痛的情感维度有关，而不是与感官辨别维度有关。前额叶接受边缘系统的密集投射。从杏仁基底外侧核(BLA)到前额叶核(PFC)的单突触投射可产生持久的突触可塑性。我们研究了高频刺激(HFS)到BLA对大鼠PFC伤害性反应的影响。HFS对PFC内伤害性神经元的特异性高阈值反应具有长时间抑制作用。微量注射N-甲基-D-天冬氨酸受体拮抗剂(2-氨基-5-磷酸丙戊酸)、地佐西平(MK-801)和代谢型谷氨酸受体拮抗剂(2-[(1S，2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine(LY341495)和α-甲基-4-羧基苯甘氨酸(MCPG))可阻断伤害性反应中LLS的诱导。我们还研究了多巴胺(DA)对伤害性反应的LLS的调制作用。向同侧前脑束注射6-羟基多巴胺(6-OHDA)引起DA耗竭后，伤害性反应的LLS降低，而伤害性反应正常。多巴胺受体亚型D2(舒必利)和D4(3-{[4-(4-氯苯基)哌嗪-1-基]甲基}-1H-吡咯并[2，3-b]吡啶(L-745,870))拮抗剂可抑制伤害性反应的LLS。我们的结果表明，BLA-PFC通路抑制了PFC伤害性感受细胞的活动，DA系统改变了BLA-PFC的调节功能。
We previously demonstrated nociceptive discharges to be evoked by mechanical noxious stimulation in the prefrontal cortex (PFC). The nociceptive responses recorded in the PFC are conceivably involved in the affective rather than the sensory-discriminative dimension of pain. The PFC receives dense projection from the limbic system. Monosynaptic projections from the basolateral nucleus of the amygdala (BLA) to the PFC are known to produce long-lasting synaptic plasticity. We examined effects of high frequency stimulation (HFS) delivered to the BLA on nociceptive responses in the rat PFC. HFS induced long lasting suppression (LLS) of the specific high threshold responses of nociceptive neurons in the PFC. Microinjection of N-methyl-D-aspartic acid (NMDA) receptor antagonists (2-amino-5-phosphonovaleric acid (APV), dizocilpine (MK-801)) and also metabotropic glutamate receptor (mGluR) group antagonists (α-methyl-4-carboxyphenylglycine (MCPG), and 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine (LY341495)), prevented the induction of LLS of nociceptive responses. We also examined modulatory effects of dopamine (DA) on the LLS of nociceptive responses. With depletion of DA in response to 6-hydroxydopamine (6-OHDA) injection into the ipsilateral forebrain bundle, LLS of nociceptive responses was decreased, while nociceptive responses were normally evoked. Antagonists of DA receptor subtypes D2 (sulpiride) and D4 (3-{[4-(4-chlorophenyl) piperazin-1-yl] methyl}-1H-pyrrolo [2, 3-b] pyridine (L-745,870)), microinjected into the PFC, inhibited LLS of nociceptive responses. Our results indicate that BLA-PFC pathways inhibited PFC nociceptive cell activities and that the DA system modifies the BLA-PFC regulatory function.
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影响因子：
5.3
作者：
Calabresi, P;Centonze, D;Bernardi, G
通讯作者：
Bernardi, G
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14.5
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Bantick, SJ;Wise, RG;Tracey, I
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Tracey, I
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Neve, KA;Seamans, JK;Trantham-Davidson, H
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Trantham-Davidson, H