Re-engineered imaging agent using biomimetic approaches.
Re-engineered imaging agent using biomimetic approaches.
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DOI：
10.1002/wnan.1762
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Aryal S
中科院分区：
文献类型：
--
作者：
Nguyen TDT;Marasini R;Aryal S
生物医学技术的最新进展--临床生物影像学对疾病的诊断、治疗和预防产生了更大的影响，尤其是通过早期干预和精确治疗。各种小分子或纳米材料形式的有机和无机材料已被设计为造影剂（CA），以提高不同组织之间的图像分辨率，用于检测异常，如癌症和血管闭塞。在众多的新型造影剂中，造影剂与生物衍生的内源性平台结合在药物输送和生物成像等生物医学领域具有广阔的应用前景。使用生物组分如细胞或细胞产物作为递送系统的策略主要减少其货物的毒性行为，因为这些系统通过将其货物导向靶向位置来减少非特异性分布。假设是，根据原始细胞的原始生物学作用，由这样的系统携带的造影剂可以提供相应的自然指定行为。因此，通过将常规合成分子和纳米材料的性质与内源性细胞体相结合，生物成像领域中克服生物屏障的新解决方案已作为创新的生物工程提供。在这篇综述中，我们将讨论细胞和细胞衍生成分的工程作为各种造影剂的输送系统，以实现临床相关的对比诊断和研究疾病进展的机制。
Recent progress in biomedical technology, the clinical bioimaging, has a greater impact on the diagnosis, treatment, and prevention of disease, especially by early intervention and precise therapy. Varieties of organic and inorganic materials either in the form of small molecules or nano-sized materials have been engineered as a contrast agent (CA) to enhance image resolution among different tissues for the detection of abnormalities such as cancer and vascular occlusion. Among different innovative imaging agents, contrast agents coupled with biologically derived endogenous platform shows the promising application in the biomedical field, including drug delivery and bioimaging. Strategy using bio-components such as cells or products of cells as a delivery system predominantly reduces the toxic behavior of its cargo, as these systems reduce non-specific distribution by navigating its cargo toward the targeted location. The hypothesis is that depending on the original biological role of the naïve cell, the contrast agents carried by such a system can provide corresponding natural designated behavior. Therefore, by combining properties of conventional synthetic molecules and nanomaterials with endogenous cell body, new solutions in the field of bioimaging to overcome biological barriers have been offered as innovative bioengineering. In this review, we will discuss the engineering of cell and cell-derived-components as a delivery system for various contrast agents to achieve clinically relevant contrast for diagnosis and study underlining mechanism of disease progression.
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