A vision for a biomedical cloud.

A vision for a biomedical cloud.
复制标题

DOI:
10.1111/j.1365-2796.2011.02491.x
复制
发表时间:
2012-02
影响因子:
11.1
通讯作者:
White KP
White KP
中科院分区:
医学1区
文献类型:
--
作者:
Grossman RL;White KP

文献摘要

参考文献

被引文献

相似文献

我们提出了一个系统医学计算云的愿景,它借鉴了基因组学,系统生物学和生物医学数据挖掘领域的进展。这些领域的成功融合将创建一个生物标志物、遗传变异和环境变量的预测矩阵,这将大大提高诊断各种常见疾病的特异性和及时性,同时提供有关治疗方案疗效的准确预测。然而,这些领域产生的数据量是惊人的,管理和分析它的任务也是惊人的,需要开发足够的计算基础设施,以便组装,管理和挖掘巨大的和快速增长的“组学”数据库沿着临床信息。我们现在已经到达了基因组技术、云计算和生物数据挖掘之间的交叉点。这个交叉点为开发一个全球适用的云计算平台提供了一个发射台,该平台能够支持数据密集型、支持云的系统医学的新范式。
We present a vision for a Systems Medicine Computing Cloud that draws on progress in the fields of Genomics, Systems Biology, and Biomedical Data Mining. The successful fusion of these areas will create a predictive matrix of biomarkers, genetic variants, and environmental variables that will drastically increase the specificity and timeliness of diagnosis for a wide range of common diseases, while delivering accurate predictions about the efficacy of treatment options. However, the amount of data being generated by each of these areas is staggering, as is the task of managing and analyzing it. Adequate computing infrastructure needs to be developed in order to assemble, manage, and mine the enormous and rapidly growing corpus of ‘omics’ data along with clinical information. We have now arrived at an intersection point between genome technology, cloud computing and biological data mining. This intersection point provides a launch pad for developing a globally applicable cloud computing platform capable of supporting a new paradigm of data intensive, cloud-enabled Systems Medicine.
DOI: 10.1371/journal.pbio.1001046
发表时间: 2011-04
期刊: PLoS biology
影响因子: 9.8
作者:
ENCODE Project Consortium
通讯作者: ENCODE Project Consortium
DOI: 10.1038/msb.2008.25
发表时间: 2008
影响因子: 9.9
作者:
Hua, Sujun;Kallen, Caleb B.;Dhar, Ruby;Baquero, Maria T.;Mason, Christopher E.;Russell, Beth A.;Shah, Parantu K.;Liu, Jiang;Khramtsov, Andrey;Tretiakova, Maria S.;Krausz, Thomas N.;Olopade, Olufunmilayo I.;Rimm, David L.;White, Kevin P.
通讯作者: White, Kevin P.
DOI: 10.1126/science.1179050
发表时间: 2009-10-09
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Amit I;Garber M;Chevrier N;Leite AP;Donner Y;Eisenhaure T;Guttman M;Grenier JK;Li W;Zuk O;Schubert LA;Birditt B;Shay T;Goren A;Zhang X;Smith Z;Deering R;McDonald RC;Cabili M;Bernstein BE;Rinn JL;Meissner A;Root DE;Hacohen N;Regev A
通讯作者: Regev A
DOI: 10.1038/ng1886
发表时间: 2006-10-01
期刊: NATURE GENETICS
影响因子: 30.8
作者:
Janssens, Hilde;Hou, Shuling;Reinitz, John
通讯作者: Reinitz, John
DOI: 10.1073/pnas.0910200107
发表时间: 2010-04-06
影响因子: 11.1
作者:
McGary, Kriston L.;Park, Tae Joo;Marcotte, Edward M.
通讯作者: Marcotte, Edward M.