Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
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DOI：
10.4049/jimmunol.1102335
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发表时间：
2011-11-15
期刊：
影响因子：
--
通讯作者：
Lefrançois L
中科院分区：
文献类型：
--
作者：
Obar JJ;Jellison ER;Sheridan BS;Blair DA;Pham QM;Zickovich JM;Lefrançois L
响应于感染，CD 8 + T细胞整合多种信号并经历细胞数量的指数增加。同时，动态分化过程发生，导致从表型为CD 127 lowKLRG 1 low的早期效应细胞（EEC）形成短寿命（SLEC; CD 127 lowKLRG 1high）和记忆前体（MPEC; CD 127 highKLRG 1 low）效应细胞。水泡性口炎病毒（VSV）感染期间的CD 8 + T细胞分化与单核细胞增生李斯特菌感染期间显著不同，EEC分化为SLECs显著减少。SLEC的发生依赖于Ebi 3的表达。此外，CpG-DNA通过IL-12依赖性机制促进VSV感染期间SLEC的分化。此外，CpG-DNA处理增强效应CD 8 + T细胞功能和记忆亚群分布，但以IL-12非依赖性方式。在二次CD 8 + T细胞应答过程中，群体动力学显著不同，SLEC的积累要多得多，并且出现大量CD 127 highKLRG 1highmemory细胞，这两者都是记忆性CD 8 + T细胞所固有的。这些子集持续了几个月，但在回忆方面不如MPEC有效。因此，我们的数据揭示了T细胞引发背景的变化如何改变下游效应和记忆CD 8 + T细胞分化。
In response to infection CD8+ T cells integrate multiple signals and undergo an exponential increase in cell numbers. Simultaneously, a dynamic differentiation process occurs, resulting in the formation of short-lived (SLEC; CD127lowKLRG1high) and memory-precursor (MPEC; CD127highKLRG1low) effector cells from an early-effector cell (EEC) that is CD127lowKLRG1low in phenotype. CD8+ T cell differentiation during vesicular stomatitis virus (VSV) infection differed significantly than during Listeria monocytogenes infection with a substantial reduction in EEC differentiation into SLECs. SLEC generationwas dependent on Ebi3 expression. Furthermore, SLEC differentiation during VSV infection wasenhanced by administration ofCpG-DNA, through an IL-12 dependent mechanism. Moreover, CpG-DNAtreatment enhanced effector CD8+ T cell functionality and memory subset distribution, but in an IL-12 independent manner. Population dynamics were dramatically different during secondary CD8+ T cell responses, with a much greater accumulation of SLECs and the appearance of a significant number of CD127highKLRG1highmemory cells, both of which were intrinsic to the memory CD8+ T cell. These subsets persisted for several months, but were less effective in recall than MPECs. Thus, our data shed light on how varying the context of T cell priming alters downstream effector and memory CD8+ T cell differentiation.
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DOI：
10.1084/jem.20052237
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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