White blood cell count and the risk of colon cancer.
White blood cell count and the risk of colon cancer.
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DOI：
10.3349/ymj.2006.47.5.646
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发表时间：
2006-10-31
影响因子：
2.4
通讯作者：
Jee SH
中科院分区：
文献类型：
--
作者：
Lee YJ;Lee HR;Nam CM;Hwang UK;Jee SH
炎症可能与结直肠癌的发病机制有关。然而，关于炎症标志物c反应蛋白（CRP）与结直肠癌风险之间的关系，最近报道了两个相互矛盾的观察结果。很少有流行病学研究调查炎症标志物与结直肠癌风险之间的关系。我们前瞻性地研究了424,419名韩国人（108,907名男性和315,512名女性）结肠癌和直肠癌的死亡率和发病率风险。研究对象年龄在40 - 95岁之间，来自韩国癌症预防研究（KCPS）队列。1993年和1995年，所有受试者都接受了国家健康保险公司的体检。最长随访期为10年，随访期自1994年1月1日起至2003年12月31日止。白细胞计数（WBC）升高与结肠癌死亡风险升高相关（最高四分位数vs最低四分位数：男性，1.55,95% CI 1.10-2.18, p for trend = 0.0014；女性，1.51,95% CI 1.12-2.03, p for trend = 0.0049）。同样，WBC升高与结肠癌发病率升高相关（最高四分位数vs最低四分位数：男性1.38,1.09-1.76，p为趋势= 0.0017；女性1.46,95% CI 1.20-1.78， p为趋势= 0.0003）。在非吸烟者中也观察到正线性趋势。白细胞与直肠癌风险之间没有显著关联。我们的研究结果表明，白细胞升高与结肠癌死亡率和发病率的增加有关。这些结果支持了我们的假设，即炎症会增加患结肠癌的风险。
Inflammation may be linked to the pathogenesis of colorectal cancer. However, two conflicting observational results were recently reported on the relationship between the inflammatory marker C-reactive protein (CRP) and the risk of colorectal cancer. Few epidemiologic studies have examined the association between inflammatory markers and the risk of colorectal cancer. We prospectively examined the mortality and incidence risk for colon and rectal cancers among 424,419 Koreans (108,907 men and 315,512 women). The subjects were 40 to 95 years of age and from the Korean Cancer Prevention Study (KCPS) cohort. All subjects received medical examination from the National Health Insurance Corporation in 1993 and 1995. The maximum follow-up period was 10 years, and the follow-up periods began in January 1, 1994 and ended in December 31, 2003. An elevated white blood cell count (WBC) was associated with a higher mortality risk of colon cancer (highest versus lowest quartile: men, 1.55, 95% CI 1.10-2.18, p for trend = 0.0014; women, 1.51, 95% CI 1.12-2.03, p for trend = 0.0049). Similarly, an elevated WBC was associated with a higher incidence risk of colon cancer (highest versus lowest quartile: men, 1.38, 1.09-1.76, p for trend = 0.0017; women, 1.46, 95% CI 1.20-1.78, p for trend = 0.0003). A positive linear trend was also observed in non-smokers. There was no significant association between WBC and the risk of rectal cancer. Our findings demonstrate that an elevated WBC is associated with an increase in both the mortality and incidence rates of colon cancer. These results support our hypothesis that inflammation increases the risk of colon cancer.
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影响因子：
3.9
作者：
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