Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency.
Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency.
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DOI：
10.2169/internalmedicine.1698-18
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发表时间：
2019-03-15
期刊：
影响因子：
--
通讯作者：
Narita I
中科院分区：
文献类型：
--
作者：
Koda R;Tsuchida M;Iino N;Narita I
一位68岁的男性，患有2型糖尿病和慢性乙肝感染，在计划进行肝细胞癌手术前转诊至肾内科。他已经接受小剂量阿德福韦酯(ADV)治疗11年。实验室结果显示，近端肾小管的重吸收受损。由于缺乏维生素D，他被诊断出患有糖尿病肾病和骨软化症；因此，直到他被推荐给我们，ADV才停止使用。在这种情况下，伴随的糖尿病和维生素D缺乏可能阻碍了ADV诱导的Fanconi综合征的早期诊断。
A 68-year-old man with type 2 diabetes mellitus and chronic hepatitis B infection was referred to the nephrology department before planned surgery for hepatocellular carcinoma. He had been receiving low-dose adefovir dipivoxil (ADV) for 11 years. Laboratory findings revealed impaired re-absorption in the proximal renal tubules. He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us. In this case, concomitant diabetes mellitus and vitamin D deficiency might have prevented the early diagnosis of ADV-induced Fanconi syndrome.
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3.3
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