Bugs That Can Resist Antibiotics but Not Men: Gender-Specific Differences in Notified Infections and Colonisations in Germany, 2010-2019.
Bugs That Can Resist Antibiotics but Not Men: Gender-Specific Differences in Notified Infections and Colonisations in Germany, 2010-2019.
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DOI：
10.3390/microorganisms9050894
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发表时间：
2021-04-22
期刊：
影响因子：
4.5
通讯作者：
Haller S
中科院分区：
文献类型：
--
作者：
Brandl M;Hoffmann A;Willrich N;Reuss A;Reichert F;Walter J;Eckmanns T;Haller S
监测网络的数据显示，男性感染耐药性病原体的发病率高于女性。我们系统地分析了德国强制监测下AMR病原体的感染和定植数据，以量化性别特异性差异。我们计算了耐甲氧西林金黄色葡萄球菌（MRSA）侵袭性感染和碳青霉烯类非敏感不动杆菌属感染或定植的每10万人年的发病率（IR）。(CRA)和肠球菌目（CRE），使用整个德国人口作为分母。我们将研究期限制为具有完整通知数据的年份（MRSA：2010-2019，CRA/CRE：2017-2019）。我们使用泊松回归来调整性别、年龄组、联邦州和通知年份。在研究期间，所有通知的IR为每100，000人年MRSA 4.2，CRA 0.90和CRE 4.8。与女性相比，MRSA、CRA和CRE的男性感染调整后IR比值分别为2.3（95%置信区间[CI]：2.2-2.3）、2.2（95% CI：1.9-2.7）和1.7（95% CI：1.6-1.8）。在德国，男性感染AMR病原体的风险是女性的两倍。在有数据的情况下，殖民地也是如此。筛查程序和相关的卫生措施可能受益于性别分层的方法。
Data from surveillance networks show that men have a higher incidence rate of infections with anti-microbial-resistant (AMR) pathogens than women. We systematically analysed data of infections and colonisations with AMR pathogens under mandatory surveillance in Germany to quantify gender-specific differences. We calculated incidence-rates (IR) per 100,000 person–years for invasive infections with Methicillin-resistant Staphylococcus aureus (MRSA), and for infections or colonisations with carbapenem-non-susceptible Acinetobacter spp. (CRA), and Enterobacterales (CRE), using the entire German population as a denominator. We limited the study periods to years with complete notification data (MRSA: 2010–2019, CRA/CRE: 2017–2019). We used Poisson regression to adjust for gender, age group, federal state, and year of notification. In the study periods, IR for all notifications were 4.2 for MRSA, 0.90 for CRA, and 4.8 for CRE per 100,000 person-–years. The adjusted IR ratio for infections of men compared to women was 2.3 (95% confidence interval [CI]: 2.2–2.3) for MRSA, 2.2 (95%CI: 1.9–2.7) for CRA, and 1.7 (95%CI: 1.6–1.8) for CRE. Men in Germany show about double the risk for infection with AMR pathogens than women. This was also true for colonisations, where data were available. Screening procedures and associated hygiene measures may profit from a gender-stratified approach.
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影响因子：
120.7
作者：
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通讯作者：
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