Contextual Learning Requires Functional Diversity at Excitatory and Inhibitory Synapses onto CA1 Pyramidal Neurons
Contextual Learning Requires Functional Diversity at Excitatory and Inhibitory Synapses onto CA1 Pyramidal Neurons
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情境学习需要 CA1 锥体神经元的兴奋性和抑制性突触的功能多样性
DOI：
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
D. Mitsushima
中科院分区：
文献类型：
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作者：
D. Mitsushima
尽管海马体在特定的背景下处理时间和空间信息，但创造记忆的编码规则是完全未知的。为了检验这一机制，我们对大鼠进行了抑制回避(IA)任务的训练，这是一种依赖海马体的快速一次试验情境学习范式。通过将疱疹病毒介导的体内基因传递与体外膜片钳记录相结合，我报告了情境学习驱动包含GluR1的AMPA受体进入CA3-CA1突触。背景记忆需要分子事件，因为传递阻滞剂在CA1中的双边表达成功地阻断了IA学习。此外，我发现传递阻断细胞的数量与学习成绩之间存在对数关系。考虑到一个要么全有要么全无的设备每个时钟可以处理1比特的数据(Nobert Wiener 1961)，对数相关性可能提供CA1神经元传递上下文信息的基本数据的证据。此外，我最近报道了乙酰胆碱作为学习依赖型突触可塑性的内在触发的关键作用。IA训练诱导CA1区ACh释放，不仅增强了AMPA受体介导的兴奋性突触，也增强了GABA A受体介导的抑制性突触。更重要的是，接受IA训练的大鼠表现出不同的兴奋性和抑制性突触输入，每个CA1神经元上的差异很大。在这里，我提出了一个新的假设，即CA1神经元上突触输入的多样性可能描述了训练后处理经验事件的细胞特有的输出。
Although the hippocampus is processing temporal and spatial information in particular context, the encoding rule creating memory is completely unknown. To examine the mechanism, we trained rats on an inhibitory avoidance (IA) task, a hippocampus-dependent rapid one-trial contextual learning paradigm. By combining Herpes virus-mediated in vivo gene delivery with in vitro patch-clamp recordings, I reported contextual learning drives GluR1-containing AMPA receptors into CA3-CA1 synapses. The molecular event is required for contextual memory, since bilateral expression of delivery blocker in CA1 successfully blocked IA learning. Moreover, I found a logarithmic correlation between the number of delivery blocking cells and learning performance. Considering that one all-or-none device can process 1-bit of data per clock (Nobert Wiener 1961), the logarithmic correlation may provides evidence that CA1 neurons transmit essential data of contextual information. Further, I recently reported critical role of acetylcholine as an intrinsic trigger of learning-dependent synaptic plasticity. IA training induced ACh release in CA1 that strengthened not only AMPA receptor-mediated excitatory synapses, but also GABA A receptor-mediated inhibitory synapses on each CA1 neuron. More importantly, IA-trained rats showed individually different excitatory and inhibitory synaptic inputs with wide variation on each CA1 neuron. Here I propose a new hypothesis that the diversity of synaptic inputs on CA1 neurons may depict cell-specific outputs processing experienced episodes after training.
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DOI：
10.1073/pnas.93.10.4693
发表时间：
1996-05
影响因子：
11.1
作者：
M. Ragozzino;Katharine E. Unick;Katharine E. Unick;Paul E. Gold
通讯作者：
M. Ragozzino;Katharine E. Unick;Katharine E. Unick;Paul E. Gold
影响因子：
158.5
作者：
Petersen, RC;Thomas, RG;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
56.9
作者：
COYLE, JT;PRICE, DL;DELONG, MR
通讯作者：
DELONG, MR
基底前脑神经元提供灵长类新皮质的主要胆碱能神经支配。
影响因子：
2.5
作者：
Struble,RG;Lehmann,J;Mitchell,SJ;McKinney,M;Price,DL;Coyle,JT;DeLong,MR
通讯作者：
DeLong,MR