Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres.
Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres.
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DOI：
10.1016/j.neuroimage.2010.05.073
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发表时间：
2011-01-01
期刊：
影响因子：
5.7
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Gee, Dylan G.;Biswal, Bharat B.;Kelly, Clare;Stark, David E.;Margulies, Daniel S.;Shehzad, Zarrar;Uddin, Lucina Q.;Klein, Donald F.;Banich, Marie T.;Castellanos, F. Xavier;Milham, Michael P.
静息态功能磁共振成像（fMRI）提供了一种新的方法来检查半球间的相互作用，证明了高度的功能连接在相对半球的同伦区域之间。然而，异位静息态功能连接（RSFC）仍然相对不确定。在本研究中，我们检查非同伦区域，表征异位RSFC和比较它的半球内RSFC，检查半球分离的整合和分离的大脑中的处理的影响。从59名健康参与者获得静息状态fMRI扫描，以检查BOLD信号中自发低频波动的区域间相关性。使用概率地图集，我们相关的概率加权的时间序列分布在整个大脑的112个区域（56个半球）。我们比较了位于不同半球的非同源区域配对的RSFC（异位连接）与位于半球内的相同配对的RSFC（半球内连接）。对于积极的连接，连接强度更大，在每个半球，整合半球内处理一致。然而，对于负连接，RSFC强度更大的半球之间，隔离半球间的处理。这些模式特别值得注意的是涉及额叶和异模态区域的连接。正连接和负连接的分布在两半球内部和两半球之间几乎是相同的，尽管我们展示了分布的详细区域差异。我们讨论了大脑半球间相互作用的主导模式的影响。未来的应用，我们的分析可能会提供重要的洞察受损的大脑半球间的处理在临床和老龄化人群。
Resting-state functional magnetic resonance imaging (fMRI) has provided a novel approach for examining interhemispheric interaction, demonstrating a high degree of functional connectivity between homotopic regions in opposite hemispheres. However, heterotopic resting state functional connectivity (RSFC) remains relatively uncharacterized. In the present study, we examine non-homotopic regions, characterizing heterotopic RSFC and comparing it to intrahemispheric RSFC, to examine the impact of hemispheric separation on the integration and segregation of processing in the brain. Resting-state fMRI scans were acquired from 59 healthy participants to examine interregional correlations in spontaneous low frequency fluctuations in BOLD signal. Using a probabilistic atlas, we correlated probability-weighted time series from 112 regions (56 per hemisphere) distributed throughout the entire cerebrum. We compared RSFC for pairings of non-homologous regions located in different hemispheres (heterotopic connectivity) to RSFC for the same pairings when located within hemisphere (intrahemispheric connectivity). For positive connections, connectivity strength was greater within each hemisphere, consistent with integrated intrahemispheric processing. However, for negative connections, RSFC strength was greater between the hemispheres, consistent with segregated interhemispheric processing. These patterns were particularly notable for connections involving frontal and heteromodal regions. The distribution of positive and negative connectivity was nearly identical within and between the hemispheres, though we demonstrated detailed regional variation in distribution. We discuss implications for leading models of interhemispheric interaction. The future application of our analyses may provide important insight into impaired interhemispheric processing in clinical and aging populations.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.6
作者：
ELLENBERG, L;SPERRY, RW
通讯作者：
SPERRY, RW
影响因子：
1.9
作者：
Bajwa, Sami;Bermpohl, Felix;Fregni, Felipe
通讯作者：
Fregni, Felipe
DOI：
10.1037/0096-1523.7.5.1031
发表时间：
1981-01-01
影响因子：
2.1
作者：
FRIEDMAN, A;POLSON, MC
通讯作者：
POLSON, MC
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.