Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes.
Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes.
复制标题
DOI：
10.1016/j.metabol.2010.09.010
复制
发表时间：
2011-01
影响因子：
9.8
通讯作者：
Kitabchi, Abbas E.
中科院分区：
文献类型：
--
作者：
Nyenwe, Ebenezer A.;Jerkins, Tern W.;Umpierrez, Guillermo E.;Kitabchi, Abbas E.
2型糖尿病的患病率在世界各地继续以惊人的速度增加，更多的人受到前驱糖尿病的影响。尽管2型糖尿病的发病机制和长期并发症是众所周知的，但其治疗仍然具有挑战性，只有一半的患者达到推荐的血红蛋白A1c目标。本文综述了2型糖尿病治疗的发病机理，以期更好地理解不断发展的治疗方式。本文还讨论了糖尿病的诊断标准，包括血红蛋白A1c在糖尿病诊断中的作用。适当的注意是给予不同的治疗演习和他们的效用在糖尿病患者的管理。支持运动，医学营养治疗，血糖监测和减肥措施，包括药物治疗和减肥手术的作用的证据进行了讨论。详细讨论了住院和门诊患者的最佳血糖控制这一有争议的问题。更新现有的药理学选择的管理2型糖尿病提供了特别强调新的和新兴的方式。特别关注的是2型糖尿病患者的胰岛素治疗，解释了非卧床糖尿病患者胰岛素治疗的病理生理学基础。还提供了对支持不同预防措施有效性的证据的审查。
The prevalence of type 2 diabetes continues to increase at an alarming rate around the world, with even more people being affected by prediabetes. Although the pathogenesis and long-term complications of type 2 diabetes are fairly well known, its treatment has remained challenging, with only half of the patients achieving the recommended hemoglobin A1c target. This narrative review explores the pathogenetic rationale for the treatment of type 2 diabetes, with the view of fostering better understanding of the evolving treatment modalities. The diagnostic criteria including the role of hemoglobin A1c in the diagnosis of diabetes are discussed. Due attention is given to the different therapeutic maneuvers and their utility in the management of the diabetic patient. The evidence supporting the role of exercise, medical nutrition therapy, glucose monitoring, and antiobesity measures including pharmacotherapy and bariatric surgery is discussed. The controversial subject of optimum glycemic control in hospitalized and ambulatory patients is discussed in detail. An update of the available pharmacologic options for the management of type 2 diabetes is provided with particular emphasis on newer and emerging modalities. Special attention has been given to the initiation of insulin therapy in patients with type 2 diabetes, with explanation of the pathophysiologic basis for insulin therapy in the ambulatory diabetic patient. A review of the evidence supporting the efficacy of the different preventive measures is also provided.
登录
查看更多内容
影响因子：
10
作者：
Baker, EH;Janaway, CH;Jones, PW
通讯作者：
Jones, PW
影响因子：
168.9
作者：
Astrup, Arne;Rossner, Stephan;Lean, Michael E. J.
通讯作者：
Lean, Michael E. J.
影响因子：
158.5
作者：
Appel, LJ;Moore, TJ;Karanja, N
通讯作者：
Karanja, N
影响因子：
158.5
作者：
Adams, Ted D.;Gress, Richard E.;Hunt, Steven C.
通讯作者：
Hunt, Steven C.
影响因子：
6.9
作者：
Brennan, Aoife M.;Sweeney, Laura L.;Liu, Xiaowen;Mantzoros, Christos S.
通讯作者：
Mantzoros, Christos S.