Gut bacteria require neutrophils to promote mammary tumorigenesis.
Gut bacteria require neutrophils to promote mammary tumorigenesis.
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DOI：
10.18632/oncotarget.3328
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发表时间：
2015-04-20
期刊：
影响因子：
--
通讯作者：
Erdman SE
中科院分区：
文献类型：
--
作者：
Lakritz JR;Poutahidis T;Mirabal S;Varian BJ;Levkovich T;Ibrahim YM;Ward JM;Teng EC;Fisher B;Parry N;Lesage S;Alberg N;Gourishetti S;Fox JG;Ge Z;Erdman SE
Recent studies suggest that gastrointestinal tract microbiota modulate cancer development in distant non-intestinal tissues. Here we tested mechanistic hypotheses using a targeted pathogenic gut microbial infection animal model with a predilection to breast cancer. FVB-Tg(C3-1-TAg)cJeg/JegJ female mice were infected by gastric gavage with Helicobacter hepaticus at three-months-of-age putting them at increased risk for mammary tumor development. Tumorigenesis was multifocal and characterized by extensive infiltrates of myeloperoxidase-positive neutrophils otherwise implicated in cancer progression in humans and animal models. To test whether neutrophils were important in etiopathogenesis in this bacteria-triggered model system, we next systemically depleted mice of neutrophils using thrice weekly intraperitoneal injections with anti-Ly-6G antibody. We found that antibody depletion entirely inhibited tumor development in this H. hepaticus-infected model. These data demonstrate that host neutrophil-associated immune responses to intestinal tract microbes significantly impact cancer progression in distal tissues such as mammary glands, and identify gut microbes as novel targets for extra-intestinal cancer therapy.
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影响因子：
50.3
作者：
Bromberg J;Wang TC
通讯作者：
Wang TC
影响因子：
3.7
作者：
Azab, Basem;Bhatt, Vijaya R.;Widmann, Warren D.
通讯作者：
Widmann, Warren D.
影响因子：
6.4
作者：
Erdman, Susan E.;Rao, Varada P.;Olipitz, Werner;Taylor, Christie L.;Jackson, Erin A.;Levkovich, Tatiana;Lee, Chung-Wei;Horwitz, Bruce H.;Fox, James G.;Ge, Zhongming;Poutahidis, Theofilos
通讯作者：
Poutahidis, Theofilos
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C
影响因子：
8.7
作者：
Franchi L;Warner N;Viani K;Nuñez G
通讯作者：
Nuñez G