The glucocorticoid receptor signalling in breast cancer.
The glucocorticoid receptor signalling in breast cancer.
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DOI：
10.1111/j.1582-4934.2007.00177.x
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发表时间：
2008-01
影响因子：
5.3
通讯作者：
Papavassiliou AG
中科院分区：
文献类型：
--
作者：
Moutsatsou P;Papavassiliou AG
糖皮质激素（GCs）作为乳腺癌化疗的联合用药，尽管一些证据表明它们的使用可能有不同的效果，实际上可能抑制化疗敏感性。气相色谱诱导的乳腺癌化疗耐药的分子基础仍不明确。最近的研究人员试图阐明潜在通路的某些方面，提供了令人信服的证据，证明GCs诱导的效应依赖于糖皮质激素受体（GR）介导的特定基因的转录调节，这些基因已知在细胞/组织功能中起关键作用，包括生长、凋亡、分化、转移和细胞存活。在这篇综述中，我们关注gc诱导的乳腺癌化疗耐药是如何由GR介导的，揭示了GR信号传导与乳腺癌中普遍存在的其他信号级联的分子相互作用。我们还详细描述了GR的结构和功能，总结了近年来获得的关于GR与其他信号级联和次级信使之间的串扰机制的数据，通过这些串扰机制，gc发挥了其多效性作用。
Glucocorticoids (GCs) are provided as co-medication with chemotherapy in breast cancer, albeit several lines of evidence indicate that their use may have diverse effects and in fact may inhibit chemosensitivity. The molecular basis of GC-induced resistance to chemotherapy in breast cancer remains poorly defined. Recent researchers, in an attempt to clarify some aspects of the underlying pathways, provide convincing evidence that GCs induce effects that are dependent upon the glucocorticoid-receptor (GR)-mediated transcriptional regulation of specific genes known to play key roles in cellular/tissue functions, including growth, apoptosis, differentiation, metastasis and cell survival. In this review, we focus on how GC-induced chemoresistance in breast cancer is mediated by the GR, unravelling the molecular interplay of GR signalling with other signalling cascades prevalent in breast cancer. We also include a detailed description of GR structure and function, summarizing data gained during recent years into the mechanism(s) of the cross-talk between the GR and other signalling cascades and secondary messengers, via which GCs exert their pleiotropic effects.
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影响因子：
19
作者：
Aoyagi, S;Archer, TK
通讯作者：
Archer, TK
影响因子：
3.3
作者：
BLASK, DE;HILL, SM;MASSA, JS
通讯作者：
MASSA, JS
影响因子：
7.5
作者：
Downward, J
通讯作者：
Downward, J
DOI：
10.1006/bbrc.2000.2626
发表时间：
2000-05-10
影响因子：
3.1
作者：
Burow, ME;Weldon, CB;McLachlan, JA
通讯作者：
McLachlan, JA
影响因子：
5.3
作者：
Brunet, A;Park, J;Greenberg, ME
通讯作者：
Greenberg, ME