Innate and Adaptive Immunity of Murine Neural Stem Cell-Derived piRNA Exosomes/Microvesicles against Pseudotyped SARS-CoV-2 and HIV-Based Lentivirus.
Innate and Adaptive Immunity of Murine Neural Stem Cell-Derived piRNA Exosomes/Microvesicles against Pseudotyped SARS-CoV-2 and HIV-Based Lentivirus.
复制标题
DOI：
10.1016/j.isci.2020.101806
复制
发表时间：
2020-12-18
期刊：
影响因子：
5.8
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Yu B;Ikhlas S;Ruan C;Zhong X;Cai D
By testing pseudotyped SARS-CoV-2 and HIV-based lentivirus, this study reports that exosomes/microvesicles (Ex/Mv) isolated from murine hypothalamic neural stem/progenitor cells (htNSC) or subtype htNSCPGHM as well as hippocampal NSC have innate immunity-like actions against these RNA viruses. These extracellular vesicles also have a cell-free innate antiviral action by attacking and degrading viruses. We further generated the induced versions of Ex/Mv through prior viral exposure to NSCs and found that these induced Ex/Mv were stronger than basal Ex/Mv in reducing the infection of these viruses, suggesting the involvement of an adaptive immunity-like antiviral function. These NSC Ex/Mv were found to be characterized by producing large libraries of P element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) against genomes of various viruses, and some of these piRNAs were enriched during the adaptive immunity-like reaction, possibly contributing to the antiviral effects of these Ex/Mv. In conclusion, NSC Ex/Mv have antiviral immunity and could potentially be developed to combat against various viruses. Murine NSC-released exosomes/microvesicles have an innate antiviral action Murine NSC-released exosomes/microvesicles can be induced adaptively to be antiviral Murine NSC-released exosomes/microvesicles can target viruses in cell-free environment Murine NSC exosomes/microvesicles produce piRNAs that are potentially antiviral Immunology; Immune Response; Virology; Stem Cell Research
登录
查看更多内容
影响因子：
7.5
作者：
Gupta S;Rawat S;Arora V;Kottarath SK;Dinda AK;Vaishnav PK;Nayak B;Mohanty S
通讯作者：
Mohanty S
影响因子：
3.9
作者：
Ma, Di;Chen, Chong-Bo;Ng, Tsz Kin
通讯作者：
Ng, Tsz Kin
DOI：
10.1126/science.1209985
发表时间：
2011-10-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Rosas-Ballina M;Olofsson PS;Ochani M;Valdés-Ferrer SI;Levine YA;Reardon C;Tusche MW;Pavlov VA;Andersson U;Chavan S;Mak TW;Tracey KJ
通讯作者：
Tracey KJ
sRNAPrimerDB：针对小非编码 RNA 的综合引物设计和搜索网络服务
影响因子：
5.8
作者：
Xie, Shengsong;Zhu, Qin;Zhao, Shuhong
通讯作者：
Zhao, Shuhong
影响因子：
64.8
作者：
Zhang Y;Kim MS;Jia B;Yan J;Zuniga-Hertz JP;Han C;Cai D
通讯作者：
Cai D