IL-17 in psoriasis: implications for therapy and cardiovascular co-morbidities.
IL-17 in psoriasis: implications for therapy and cardiovascular co-morbidities.
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DOI：
10.1016/j.cyto.2013.03.013
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发表时间：
2013-05
期刊：
影响因子：
3.8
通讯作者：
Ward, Nicole L.
中科院分区：
文献类型：
--
作者：
Golden, Jackelyn B.;McCormick, Thomas S.;Ward, Nicole L.
银屑病是一种流行的慢性皮肤炎性疾病，由表皮角质形成细胞、真皮血管细胞和免疫细胞（包括活化的抗原呈递细胞（APC）、单核细胞/巨噬细胞以及Th 1和Th 17细胞）之间发生的串扰介导。角质形成细胞和内皮细胞的增殖增加与免疫细胞浸润一起导致明显的表皮和血管增生，这是银屑病皮损皮肤的特征。活化的T细胞与单核细胞/巨噬细胞的相互作用通过Th 17/IL-23轴发生，并且对于维持慢性炎症至关重要。最近的流行病学证据表明，银屑病患者患心血管疾病和死亡的风险增加。银屑病和心血管疾病之间的相似病理学，包括关键免疫细胞群的参与以及常见炎症介质如IL-17 A的释放，表明两种疾病之间存在机制联系。本文将重点介绍银屑病发病机制的关键概念、银屑病的全身表现、IL-17在银屑病和心血管疾病中的作用以及IL-17在银屑病患者中介导心血管并发症的潜在作用。
Psoriasis is a prevalent, chronic inflammatory disease of the skin mediated by cross-talk occurring between epidermal keratinocytes, dermal vascular cells and immunocytes, including activated antigen presenting cells (APCs), monocytes/macrophages, and Th1 and Th17 cells. Increased proliferation of keratinocytes and endothelial cells in conjunction with immune cell infiltration leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Interaction of activated T cells with monocytes/macrophages occurs via the Th17/IL-23 axis and is crucial for maintaining the chronic inflammation. Recent epidemiological evidence has demonstrated that psoriasis patients have an increased risk of developing and dying of cardiovascular disease. Similar pathology between psoriasis and cardiovascular disease, including involvement of key immunologic cell populations together with release of common inflammatory mediators such as IL-17A suggest a mechanistic link between the two diseases. This review will focus on concepts critical to psoriasis pathogenesis, systemic manifestations of psoriasis, the role of IL-17 in psoriasis and cardiovascular disease and the potential role for IL-17 in mediating cardiovascular co-morbidities in psoriasis patients.
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影响因子：
3.5
作者：
Bowcock, AM;Shannon, W;Menter, A
通讯作者：
Menter, A
DOI：
10.1111/j.1365-2133.2010.09941.x
发表时间：
2010-09
期刊：
The British journal of dermatology
影响因子：
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作者：
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影响因子：
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作者：
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Sallusto, Federica
影响因子：
5
作者：
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通讯作者：
Boehncke, Sandra
急性冠脉综合征患者Th17/Treg失衡
影响因子：
8.6
作者：
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通讯作者：
Liao, Yu-hua