Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis.
Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis.
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DOI：
10.1002/acn3.646
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发表时间：
2018-11
影响因子：
5.3
通讯作者：
McCauley JL
中科院分区：
文献类型：
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作者：
Amezcua L;Beecham AH;Delgado SR;Chinea A;Burnett M;Manrique CP;Gomez R;Comabella M;Montalban X;Ortega M;Tornes L;Lund BT;Islam T;Conti D;Oksenberg JR;McCauley JL
与美国西部的白人相比，患有多发性硬化症（MS）的西班牙裔患者更年轻，更常出现视神经炎（ON）。与拉美裔基因混合有关的地区差异可能是原因所在。我们调查了西班牙人全球遗传血统、ON和MS发病年龄之间的关系。从2016年1月至2017年4月美国四个学术机构的四个基于MS的登记处获得了1033名自认为患有MS的西班牙裔患者的数据。采用多变量回归模型，利用印第安人（NA）、非洲人和欧洲人祖先的遗传祖先估计，评估遗传祖先与ON表现和MS发病年龄（定义为首次症状的年龄）之间的关系。遗传血统和ON比例因地区而异，在美国西南部的西班牙裔中，NA血统和ON比例最高（40%对19%，38%对25%）。NA与欧洲血统呈显著负相关（r = - 0.83）。ON的出现与发病年龄更小（OR: 0.98; 95% CI: 0.96-0.99; P = 7.80 × 10 - 03）和NA血统增加相关（NA血统最高四分位数vs最低四分位数OR: 2.35; 95% CI: 1.35-4.10; P = 2.60 × 10 - 03）。发病年龄越小，NA （Beta值：−5.58;P = 3.49 × 10−02）和非洲血统（Beta值：−10.07;P = 1.39 × 10−03）的比例越高。与遗传混合相关的种族差异可能影响西班牙裔MS患者的临床表现；强调在未来的西班牙裔临床、遗传和表观遗传研究中考虑遗传亚结构的重要性。
Hispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. We investigated the association between global genetic ancestry and ON and age at onset of MS in Hispanics. Data were obtained for 1033 self‐identified Hispanics with MS from four MS‐based registries from four academic institutions across the United States January 2016–April 2017. Multivariate regression models, utilizing genetic ancestry estimates for Native American (NA), African, and European ancestry, were used to assess the relationship between genetic ancestry and ON presentation and age of MS onset, defined as age at first symptom. Genetic ancestry and ON proportions varied by region where NA ancestry and ON proportions were highest among Hispanics in the southwestern United States (40% vs. 19% overall for NA and 38% vs. 25% overall for ON). A strong inverse correlation was observed between NA and European ancestry (r = −0.83). ON presentation was associated with younger age of onset (OR: 0.98; 95% CI: 0.96–0.99; P = 7.80 × 10−03) and increased NA ancestry (OR: 2.35 for the highest versus the lowest quartile of NA ancestry; 95% CI: 1.35–4.10; P = 2.60 × 10−03). Younger age of onset was found to be associated with a higher proportion NA (Beta: −5.58; P = 3.49 × 10−02) and African ancestry (Beta: −10.07; P = 1.39 × 10−03). Ethnic differences associated with genetic admixture could influence clinical presentation in Hispanics with MS; underscoring the importance of considering genetic substructure in future clinical, genetic, and epigenetic studies in Hispanics.
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影响因子：
--
作者：
Cree, Bruce A. C.;Reich, David E.;Khan, Omar;De Jager, Philip L.;Nakashima, Ichiro;Takahashi, Toshiyuki;Bar-Or, Amit;Tong, Christine;Hauser, Stephen L.;Oksenberg, Jorge R.
通讯作者：
Oksenberg, Jorge R.
影响因子：
4
作者：
Amezcua, Lilyana;Conti, David V.;Liu, Lihua;Ledezma, Karina;Langer-Gould, Annette M.
通讯作者：
Langer-Gould, Annette M.
影响因子：
5.8
作者：
Amezcua, L.;Lund, B. T.;Islam, T.
通讯作者：
Islam, T.
影响因子：
9.9
作者：
Langer-Gould, Annette;Brara, Sonu M.;Zhang, Jian L.
通讯作者：
Zhang, Jian L.
影响因子：
1.9
作者：
Langille, Megan M.;Islam, Talat;Amezcua, Lilyana
通讯作者：
Amezcua, Lilyana