A high salt diet alters pressure-induced mechanical activity of the rat lymphatics with enhancement of myogenic characteristics.
A high salt diet alters pressure-induced mechanical activity of the rat lymphatics with enhancement of myogenic characteristics.
复制标题
高盐饮食改变了压力诱导的大鼠淋巴管的机械活动，增强了生肌特征。
DOI：
10.1089/lrb.2014.0028
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fujita T.
中科院分区：
文献类型：
--
作者：
Mizuno R;Isshiki M;Ono N;Nishimoto M;Fujita T.
背景：淋巴系统已成为盐敏感性高血压动物发病机制的新参与者。高盐饮食（HSD）引起啮齿动物皮肤中Na+的积累。作为对Na+-蛋白多糖复合物增加的反应，浸润的巨噬细胞刺激血管内皮生长因子（VEGF）-C的分泌。巨噬细胞来源的VEGF-C增加真皮毛细淋巴管的密度，表明淋巴管生成通过缓冲升高的血压而对高血压动物有利。然而，一个高盐饮食（HSD）的机械活动的收集淋巴管，直接连接与淋巴毛细血管的变化的影响，还没有被determined.Methods和结果：在机械活动的变化，孤立的收集在正常盐饮食（NSD）和HSD大鼠在管腔内压力增加的反应，通过视频显微镜测量。与NSD血管相比，HSD血管具有较小的%活动直径（最大和最小）和较高的振幅。HSD大鼠的淋巴振荡频率较NSD大鼠维持得更好。HSD大鼠的淋巴泵效率（包括每搏输出量指数（SVI）、频率乘SVI、振幅乘频率）显著高于NSD大鼠。因此，一个HSD增强了抵抗压力引起的淋巴泵efficiency.Conclusions的下降：presentex vivostudy表明，收集大鼠的神经系统增强生肌活性和淋巴泵的效率，以补偿增加淋巴流量和/或压力后2周盐负荷。
Background:The lymphatic system has become a new player for pathogenesis in salt-sensitive hypertension animals. A high salt diet (HSD) evokes accumulation of Na+in the skin of rodents. In response to increase in Na+-proteoglycan complex, infiltrated macrophages stimulate secretion of vascular endothelial growth factor (VEGF)-C. Macrophage-derived VEGF-C increases density of the dermal lymph capillaries, indicating that lymphangiogenesis is advantageous to hypertensive animals by buffering elevated blood pressure. However, the effects of a high salt diet (HSD) on changes in mechanical activity of collecting lymph vessels, which directly connect with lymph capillaries, have not yet been determined.Methods and Results:Changes in mechanical activity of isolated collecting lymphatics in normal salt diet (NSD) and HSD rats in response to increase in intraluminal pressures were measured by video-microscopy. HSD vessels had smaller % active diameters (maximum and minimum) and higher amplitude compared with NSD vessels. The frequency of lymphatic oscillation was better maintained in HSD rats than in NSD. Lymphatic pump efficiency including stroke volume index (SVI), frequency times SVI, and amplitude times frequency in HSD rats were significantly higher than those of NSD. Thus, a HSD enhances the resistance to pressure-induced decreases in lymphatic pump efficiency.Conclusions:The presentex vivostudy suggest that collecting lymphatics of rats enhance myogenic activity and lymphatic pump efficiency to compensate for increase in lymph flow and/or pressure after 2 weeks salt loading.
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影响因子：
1.4
作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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