Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: observations from a post-mortem 3 Tesla imaging study.
Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: observations from a post-mortem 3 Tesla imaging study.
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DOI：
10.1016/j.jns.2009.03.021
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发表时间：
2009-07-15
影响因子：
4.4
通讯作者：
McFarland, Henry
中科院分区：
文献类型：
--
作者：
Bagnato, Francesca;Yao, Bing;Cantor, Fredric;Merkle, Hellmut;Condon, Ellen;Montequin, Marcela;Moore, Sandra;Quezado, Martha;Tkaczyk, Deborah;McFarland, Henry
新皮质病变（NL）是多发性硬化症（MS）病理学的重要组成部分，并可能导致部分身体和认知障碍。使用磁共振成像（MRI）可视化MS患者的NL提出了几个重大挑战。我们优化了反转时间（TI）的T1为基础的磁化准备的快速采集梯度回波（MPH）图像抑制病变的信号，并提高其外观为低强度，衍生的定量T1测量的基础上。后者是通过2D反转恢复快速自旋回波（IR-FSE），重复使用不同的反转时间（TI）。比较了MPWI、双回波T2和质子密度加权（PDW）图像对NLS的检测。使用配备有多通道线圈的3特斯拉磁体（3 T）对来自已故MS患者的四个冠状脑切片和来自两个先前健康供体的两个冠状脑切片进行成像。基于从MS样本计算的平均T1值以及目视检查，选择380 msec的最佳TI用于MPPT图像。在两名健康供体的标本中未观察到NLs。在观察到的40个总NL中，8个（20%）在所用的所有三个序列中可见。3个（7.5%）NL仅在PDW图像中可见，5个（12.5%）仅在T2 W图像中可见。4个NL（10%）在MPPT图像中具有明显独特的显著性。其中，3例在PDW图像（1个NL）或T2 W图像（2个NL）中进行了回顾性评分。我们的结论是，对于MS相关的NLS的检测，高分辨率的T1-基于MPEG4和T2-W图像提供了互补的信息，这两个图像序列的组合是至关重要的，以提高检测MS诱导的NLS的灵敏度。
Neocortical lesions (NLs) are an important component of multiple sclerosis (MS) pathology and may account for part of the physical and cognitive disability. Visualizing NLs of patients with MS using magnetic resonance imaging (MRI) poses several significant challenges. We optimized the inversion time (TI) of T1-based magnetization-prepared rapid acquisition gradient-echo (MPRAGE) images by suppressing the signal of the lesions and enhancing their appearance as hypointensities, on the basis of the derived quantitative T1 measurements. The latter were achieved by the means of 2D inversion recovery fast spin echo (IR-FSE), repeated using different inversion times (TI). Comparisons of detection of NLs by MPRAGE and dual echo T2 and proton density-weighted (PDW) images were made. Four coronal brain slices from a deceased MS patient and two coronal brain slices from two formerly healthy donors were imaged using a 3 Tesla magnet (3T) equipped with a multi-channel coil. Based upon the averaged T1 values computed from the MS specimen as well as visual inspection, an optimal TI of 380 msec was selected for the MPRAGE image. No NLs were seen in the specimens of the two healthy donors. Of the 40 total NLs observed, 8 (20%) were visible in all three sequences employed. Three (7.5%) NLs were visible only in the PDW image and 5 (12.5%) were seen only in the T2W image. Four NLs (10%) had clearly unique conspicuity in the MPRAGE image. Of those, 3 were retrospectively scored in the PDW image (1 NL) or in the T2W image (2 NLs). We conclude that for the detection of MS-related NLs, high resolution T1-based MPRAGE and T2-W images offer complementary information and the combination of the two image sequences is crucial for increasing the sensitivity of detecting MS-induced NLs.
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影响因子：
3.3
作者：
Deoni, SCL;Peters, TM;Rutt, BK
通讯作者：
Rutt, BK
影响因子：
5.9
作者：
Papanikolaou, N;Papadaki, E;Gourtsoyiannis, N
通讯作者：
Gourtsoyiannis, N
影响因子：
19.7
作者：
Vrenken, Hugo;Geurts, Jeroen J. G.;Pouwels, Petra J. W.
通讯作者：
Pouwels, Petra J. W.
人脑高场MRI的敏感性对比与组织铁含量的关系。
影响因子：
5.7
作者：
Yao B;Li TQ;Gelderen Pv;Shmueli K;de Zwart JA;Duyn JH
通讯作者：
Duyn JH
DOI：
10.1073/pnas.0610821104
发表时间：
2007-07-10
影响因子：
11.1
作者：
Duyn, Jeff H.;van Gelderen, Peter;Fukunaga, Masaki
通讯作者：
Fukunaga, Masaki