Growth Hormone and IGF-I as Anabolic Partitioning Hormones

Growth Hormone and IGF-I as Anabolic Partitioning Hormones
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生长激素和 IGF-I 作为合成代谢分配激素

DOI:
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发表时间:
1995
期刊:
影响因子:
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通讯作者:
D. Clemmons
D. Clemmons
中科院分区:
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文献类型:
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作者:
D. Clemmons

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生长激素(GH)是一种合成代谢激素,刺激正常志愿者的蛋白质合成。虽然它也刺激蛋白质催化剂,但蛋白质合成的增加显著大于伴随的催化剂增加,导致净蛋白质增加。两种类型的干预措施已被用来诱导正常志愿者的catastrophic。这些措施包括热量限制和糖皮质激素的管理(1,2)。接受高剂量泼尼松诱导氮损失的正常志愿者对GH有反应,氮平衡显著改善,非氧化性亮氨酸代谢增加,这是刺激蛋白质合成的指标(3)。同样,在热量限制正常志愿者的几项研究表明,GH导致蛋白质的保护(4,5)。
Growth hormone (GH) is an anabolic hormone that stimulates protein synthesis in normal volunteers. Although it also stimulates protein catabolism, the increase in protein synthesis is significantly greater than the concomitant increase in catabolism, resulting in net protein accretion. Two types of interventions have been used to induce catabolism in normal volunteers. These include caloric restriction and administration of glucocorticoids (1, 2). Normal volunteers who received high doses of prednisone to induce nitrogen loss responded to GH with significant improvement in nitrogen balance and an increase in nonoxidative leucine metabolism, which is an index of stimulation of protein synthesis (3). Similarly, several studies in calorically restricted normal volunteers have shown that GH results in protein conservation (4, 5).
在重症监护室使用人类生长激素并结合营养支持。
DOI: 10.1177/0148607190014006574
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