Dynamic aspect of reactive oxygen and nitric oxide in oral cavity.
Dynamic aspect of reactive oxygen and nitric oxide in oral cavity.
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DOI：
10.3164/jcbn.2008002
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发表时间：
2008-01
影响因子：
2.4
通讯作者：
Inoue M
中科院分区：
文献类型：
--
作者：
Sato EF;Choudhury T;Nishikawa T;Inoue M
口腔粘膜是内外环境之间的重要保护界面。因此，它必须成为环境中大量微生物物种的屏障。唾液是提供口腔环境的重要因素，并且它以这种方式对宿主防御反应是不可缺少的。口腔中性粒细胞也是在这种复杂环境中维持健康和疾病之间平衡的重要贡献者。它们产生活性氧、一氧化氮和几种抗菌肽和酶。中性粒细胞和唾液都以重叠但独立的方式有助于维持口腔的健康。除了由嗜中性粒细胞和巨噬细胞产生外，一些细菌还可以产生超氧化物、过氧化氢和一氧化氮。富含硝酸盐的蔬菜的膳食摄入可能通过一氧化氮（NO）及其相关代谢产物的胃肠道唾液循环在保护口腔和胃免受有害病原体的侵害方面发挥重要作用。本文就口腔防御系统及活性氧和NO代谢的研究进展作一综述。
Oral mucosa is a critical protective interface between external and internal environments. Therefore, it must serve as a barrier to a huge number of microbial species present in the environment. Saliva is an important factor that provides for the environment in the oral cavity, and it is indispensable to the host defense reaction in this manner. Oral neutrophils are also important contributors to maintaining the balance between health and disease in this complex environment. These produce reactive oxygen species, nitric oxide, and several antimicrobial peptides, and enzymes. Neutrophils and saliva all contribute to the maintaining the health of the oral cavity in overlapping but independent ways. In addition to production by neutrophils and macrophage, some bacteria can also generate superoxide, hydrogen peroxide, and nitric oxide. Dietary intake of nitrate-enriched vegetables might play important roles in the protection of the oral and stomach against hazardous pathogens via the gastro-intestinal-salivary cycle of nitric oxide (NO) and related metabolites. This review will focus on defense system of the human oral cavity and metabolism of reactive oxygen and NO.
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DOI：
10.1165/ajrcmb/7.5.507
发表时间：
1992-11-01
影响因子：
6.4
作者：
COX, G;GAULDIE, J;JORDANA, M
通讯作者：
JORDANA, M
影响因子：
3.9
作者：
AKIMARU, K;UTSUMI, T;UTSUMI, K
通讯作者：
UTSUMI, K
影响因子：
3.1
作者：
ANDERSON, DM;EBERSOLE, JL;NOVAK, MJ
通讯作者：
NOVAK, MJ
影响因子：
3.2
作者：
Nishiyama, Y;Massey, V;Niimura, Y
通讯作者：
Niimura, Y
影响因子：
6.4
作者：
Huycke, MM;Joyce, W;Wack, MF
通讯作者：
Wack, MF