ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans.
ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans.
复制标题
DOI：
10.1038/s41467-023-43613-4
复制
发表时间：
2023-11-24
影响因子：
16.6
通讯作者：
Chen, Di
中科院分区：
文献类型：
--
作者：
Wang, Zi;Zou, Lina;Zhang, Yiyan;Zhu, Mengnan;Zhang, Shuxian;Wu, Di;Lan, Jianfeng;Zang, Xiao;Wang, Qi;Zhang, Hanxin;Wu, Zixing;Zhu, Huanhu;Chen, Di
饮食限制是跨物种的有效抗衰老干预措施。然而，从代谢方面的观点的分子机制仍然是探索不足。在这里，我们显示ACS-20作为饮食限制对健康老龄化的关键介质，从C。线虫酰基辅酶A合成酶家族。ACS-20在发育过程中在表皮中起作用，以调节饮食限制诱导的寿命。功能转录组学研究表明，PTR-8/Patched的表达升高是acs-20蛋白质稳态和寿命缺陷的原因。此外，保守的NHR-23核受体作为ptr-8的转录抑制因子和饮食限制诱导的长寿的关键调节因子。从机制上讲，ptr-8启动子中的特定区域在饮食限制下介导转录调控和寿命延长中起着关键作用。总之，这些发现确定了一个高度保守的脂质代谢酶作为饮食限制诱导的寿命和健康寿命延长的关键介质，并揭示了下游转录调控机制。限制饮食是延缓衰老最有效的方法之一。在这里，作者发现一个高度保守的脂质代谢基因通过转录调控机制来调节蛋白质稳态，寿命和健康寿命，以响应低营养素。优雅的。
Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from a genetic screen of the C. elegans acyl-CoA synthetase family. ACS-20 functions in the epidermis during development to regulate dietary restriction-induced longevity. Functional transcriptomics studies reveal that elevated expression of PTR-8/Patched is responsible for the proteostasis and lifespan defects of acs-20. Furthermore, the conserved NHR-23 nuclear receptor serves as a transcriptional repressor of ptr-8 and a key regulator of dietary restriction-induced longevity. Mechanistically, a specific region in the ptr-8 promoter plays a key role in mediating the transcription regulation and lifespan extension under dietary restriction. Altogether, these findings identify a highly conserved lipid metabolism enzyme as a key mediator of dietary restriction-induced lifespan and healthspan extension and reveal the downstream transcriptional regulation mechanisms. Dietary restriction is one of the most effective ways to delay ageing. Here, the authors discover a highly conserved lipid metabolism gene functions through transcriptional regulation mechanisms to regulate proteostasis, lifespan and healthspan in response to low nutrients in C. elegans.
登录
查看更多内容
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
--
作者：
Chisholm, Andrew D.;Xu, Suhong
通讯作者：
Xu, Suhong
影响因子：
11.4
作者：
BRAAKMAN, I;HELENIUS, J;HELENIUS, A
通讯作者：
HELENIUS, A
影响因子：
64.8
作者：
Honjoh, Sakiko;Yamamoto, Takuya;Nishida, Eisuke
通讯作者：
Nishida, Eisuke