Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy.
Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy.
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DOI：
10.1038/s41598-021-03414-5
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发表时间：
2021-12-17
影响因子：
4.6
通讯作者：
Rolston JD
中科院分区：
文献类型：
--
作者：
Anderson DN;Charlebois CM;Smith EH;Arain AM;Davis TS;Rolston JD
在这项研究中，我们量化了一组使用表面电极和深部电极的癫痫患者在颅内脑电图期间的灰色和白色物质的覆盖范围。我们纳入了65名患者，其中包括条形电极（n = 12）、条形和网格电极（n = 24）、条形、网格和深度电极（n = 7）或仅深度电极（n = 22）。患者特异性成像用于生成概率灰度和白色物质图和图谱分割。灰色和白色物质的覆盖范围进行了量化，使用球形体积中心的电极质心，半径范围从1到15毫米，沿着详细的有限元模型的局部电场。灰质覆盖率高度依赖于所选择的影响半径（RoI）。使用2.5 mm RoI，深度电极比表面电极覆盖更多的灰质;然而，在RoI大于4 mm时，表面电极覆盖更多的灰质。在所有ROI下，深部电极的白色物质覆盖率以及杏仁核和海马覆盖率最大。本研究提供了第一个概率分析，以量化不同颅内记录配置的覆盖范围。如果所需信号是局部的，则深度电极提供比其他记录策略更大的灰质覆盖范围，而如果所需信号是扩散的，则硬膜下网格和条带采样更多的灰质。
In this study, we quantified the coverage of gray and white matter during intracranial electroencephalography in a cohort of epilepsy patients with surface and depth electrodes. We included 65 patients with strip electrodes (n = 12), strip and grid electrodes (n = 24), strip, grid, and depth electrodes (n = 7), or depth electrodes only (n = 22). Patient-specific imaging was used to generate probabilistic gray and white matter maps and atlas segmentations. Gray and white matter coverage was quantified using spherical volumes centered on electrode centroids, with radii ranging from 1 to 15 mm, along with detailed finite element models of local electric fields. Gray matter coverage was highly dependent on the chosen radius of influence (RoI). Using a 2.5 mm RoI, depth electrodes covered more gray matter than surface electrodes; however, surface electrodes covered more gray matter at RoI larger than 4 mm. White matter coverage and amygdala and hippocampal coverage was greatest for depth electrodes at all RoIs. This study provides the first probabilistic analysis to quantify coverage for different intracranial recording configurations. Depth electrodes offer increased coverage of gray matter over other recording strategies if the desired signals are local, while subdural grids and strips sample more gray matter if the desired signals are diffuse.
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影响因子：
5.7
作者：
Irimia, Andrei;Van Horn, John Darrell;Halgren, Eric
通讯作者：
Halgren, Eric
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4.3
作者：
Charlebois CM;Caldwell DJ;Rampersad SM;Janson AP;Ojemann JG;Brooks DH;MacLeod RS;Butson CR;Dorval AD
通讯作者：
Dorval AD
影响因子：
--
作者：
Lachaux, JP;Rudrauf, D;Kahane, P
通讯作者：
Kahane, P
影响因子：
4.8
作者：
Joswig, Holger;Lau, Jonathan C.;Steven, David A.
通讯作者：
Steven, David A.