Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis.
Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis.
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DOI：
10.1016/j.neurobiolaging.2017.05.006
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发表时间：
2017-09
影响因子：
4.2
通讯作者：
Samanez-Larkin GR
中科院分区：
文献类型：
--
作者：
Karrer TM;Josef AK;Mata R;Morris ED;Samanez-Larkin GR
许多认知衰老理论都基于多巴胺 (DA) 随着年龄增长而下降的证据。在这里，我们对健康成年人中年龄对不同 DA 靶点（受体、转运蛋白或相关酶）的平均影响进行了横断面 PET 和 SPECT 研究的系统荟萃分析（N=95 项研究，包括 2,611 名受试者）。结果显示，年龄对 DA 转运蛋白和受体有显着的中度至较大的负面影响。年龄对 D1 样受体的影响明显大于 D2 样受体。相比之下，年龄对DA合成能力没有显着影响。整个 DA 系统的平均年龄每十年下降 3.7-14.0%。元回归发现，只有 DA 目标可以作为年龄效应的重要调节因素。这项研究精确量化了先前关于 DA 功能随年龄下降的说法。它还确定了突触前机制（合成能力的保留和多巴胺转运蛋白的减少），这可能部分解释了以前无法解释的现象，即老年人似乎可以有效地利用多巴胺能资源。提供了对未来研究的建议，包括所需的最小样本量。
Many theories of cognitive aging are based on evidence that dopamine (DA) declines with age. Here we performed a systematic meta-analysis of cross-sectional PET and SPECT studies on the average effects of age on distinct DA targets (receptors, transporters, or relevant enzymes) in healthy adults (N=95 studies including 2,611 subjects). Results revealed significant moderate to large, negative effects of age on DA transporters and receptors. Age had a significantly larger effect on D1- than D2-like receptors. In contrast, there was no significant effect of age on DA synthesis capacity. The average age reductions across the DA system were 3.7–14.0% per decade. A meta-regression found only DA target as a significant moderator of the age effect. This study precisely quantifies prior claims of reduced DA functionality with age. It also identifies presynaptic mechanisms (spared synthesis capacity and reduced DA transporters) that may partially account for previously unexplained phenomena whereby older adults appear to use dopaminergic resources effectively. Recommendations for future studies including minimum required samples sizes are provided.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
4.2
作者：
Backman, Lars;Karlsson, Sari;Nyberg, Lars
通讯作者：
Nyberg, Lars
影响因子：
2.3
作者：
Dagher, A;Bleicher, C;Cumming, P
通讯作者：
Cumming, P
影响因子：
8.2
作者：
Braver, TS;Barch, DA
通讯作者：
Barch, DA
DOI：
10.1073/pnas.0802127105
发表时间：
2008-09-30
影响因子：
11.1
作者：
Dreher, Jean-Claude;Meyer-Lindenberg, Andreas;Berman, Karen Faith
通讯作者：
Berman, Karen Faith