Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic.
Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic.
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DOI：
10.1016/j.jhazmat.2021.126125
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发表时间：
2021-08-15
影响因子：
13.6
通讯作者：
Barcelo D
中科院分区：
文献类型：
--
作者：
Kumar M;Dhangar K;Thakur AK;Ram B;Chaminda T;Sharma P;Kumar A;Raval N;Srivastava V;Rinklebe J;Kuroda K;Sonne C;Barcelo D
持续的COVID-19大流行增加了抗菌物质（ABS）的消耗，原因是无法获得批准的疫苗。为了评估在COVID-19大流行期间不谨慎消费ABS的影响，我们比较了2020年大肠杆菌（E.大肠杆菌），2018年在印度阿赫梅达巴德进行了类似的调查，使用SARS-CoV-2基因检测作为ABS使用的标志。我们发现，与2018年相比，2020年环境水体中的ADR显著增加，非氟喹诺酮类药物的ADR大肠杆菌发生率更高。SARS-CoV-2基因组有效拷贝数与ADR发生率相关。ADR的发生率取决于污水处理厂的效率及其附近的集水面积。在2018年的研究中，ADR的患病率呈离散分布，记录的最大ADR患病率约为60%;而目前的ADR均质增加，从河流（Sabarmati）和湖泊（Alcohola和Kankaria）样本中分离的培养大肠杆菌中的最大ADR高达85%。此外，与环境沃茨相比，废水处理厂的增加较少，这最终意味着，尽管SARS-CoV-2基因和粪便污染可能在环境沃茨中被稀释，如低Ct值和大肠杆菌计数所示，但不能消除相关后果的危险，如ADR增加。非氟喹诺酮类药物的耐药率高于喹诺酮类药物。总的来说，这可能是有史以来第一次通过废水监测追踪COVID-19大流行对抗药性（ADR）流行的影响，并暗示监测其他环境健康参数的升级。这项研究将使公众和投保人关注在任何治疗过程中抗生素的最佳使用。
The ongoing COVID-19 pandemic increases the consumption of antimicrobial substances (ABS) due to the unavailability of approved vaccine(s). To assess the effect of imprudent consumption of ABS during the COVID-19 pandemic, we compare the 2020 prevalence of antidrug resistance (ADR) of Escherichia coli (E. coli) with a similar survey carried out in 2018 in Ahmedabad, India using SARS-CoV-2 gene detection as a marker of ABS usage. We found a significant ADR increase in 2020 compared to 2018 in ambient water bodies, harbouring a higher incidence of ADR E.coli towards non-fluoroquinolone drugs. Effective SARS-CoV-2 genome copies were found to be associated with the ADR prevalence. The prevalence of ADR depends on the efficiency of WWTPs (Wastewater Treatment Plants) and the catchment area in its vicinity. In the year 2018 study, prevalence of ADR was discretely distributed, and the maximum ADR prevalence recorded was ~ 60%; against the current homogenous ADR increase, and up to 85% of maximum ADR among the incubated E.coli isolated from the river (Sabarmati) and lake (Chandola and Kankaria) samples. Furthermore, wastewater treatment plants showed less increase in comparison to the ambient waters, which eventually imply that although SARS-CoV-2 genes and faecal pollution may be diluted in the ambient waters, as indicated by low Ct-value and E.coli count, the danger of related aftermath like ADR increase cannot be nullified. Also, Non-fluoroquinolone drugs exhibited overall more resistance than quinolone drugs. Overall, this is probably the first-ever study that traces the COVID-19 pandemic imprints on the prevalence of antidrug resistance (ADR) through wastewater surveillance and hints at monitoring escalation of other environmental health parameters. This study will make the public and policyholders concerned about the optimum use of antibiotics during any kind of treatment.
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